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簡要描述：1號染色體開放閱讀框77抗體免 疫 原；KLH conjugated synthetic peptide derived from human C1orf77: 31-130/248
產(chǎn)品型號：GOY-01K4438廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：176產(chǎn)品分類
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1號染色體開放閱讀框77抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
1號染色體開放閱讀框77抗體 | C1orf77 | GOY-01K4438 |
商品屬性：
英文名稱: C1orf77
中文名:1號染色體開放閱讀框77抗體
別 名；Chromatin target
of PRMT1 protein; Chromosome 1 open reading frame 77; CHTOP; CHTOP_HUMAN;
DKFZp547E1010; FOP; Friend of PRMT1 protein; MGC131924; MGC86949;
OTTHUMP00000035122; OTTHUMP00000035123; Pp7704; RP1 178F15.2; Small arginine-
and glycine-rich protein; Small protein rich in arginine and glycine; SRAG.
研究領(lǐng)域；細胞生物 免疫學(xué)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；26kDa
細胞定位；細胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human C1orf77: 31-130/248
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M TBS(pH7.4)
with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
C1orf77, also known as Friend of PRMT1 protein, is
a 248 amino acid protein that plays an essential role in the ligand-dependent
activation of estrogen receptor target genes. C1orf77 is tightly associated
with chromatin and is modified by both asymmetric and symmetric arginine
methylation. Depletion of C1orf77 results in almost complete block of
estradiol-induced promter occupancy by the estrogen receptor. Also, complete
knockdown of C1orf77 mRNA in adult erythroid progenitors stongly induces
fetal hemoglobin, suggesting that C1orf77 is a critical modulator of γ-globin gene expression. There are two isoforms of
C1orf77 that are produced as a result of alternative splicing events. The
gene encoding C1orf77 maps to human chromosome 1, the largest human
chromosome spanning about 260 million base pairs and making up 8% of the
human genome. There are about 3,000 genes on chromosome 1, and considering
the great number of genes there are also a large number of diseases
associated with chromosome 1. Function: Plays an important role in the ligand-dependent
activation of estrogen receptor target genes. May play a role in the
silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading
to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target
genes. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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