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簡要描述：補體C4a+C4b蛋白抗體免 疫 原；KLH conjugated synthetic peptide derived from human C4a and C4b Complement C4 beta chain: 21-120/1744
產(chǎn)品型號：GOY-01K1184廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：149產(chǎn)品分類
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補體C4a+C4b蛋白抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
補體C4a+C4b蛋白抗體 | C4a+C4b | GOY-01K1184 |
商品屬性：
英文名稱: C4a+C4b
中文名:補體C4a+C4b蛋白抗體
別 名；Complement C4
beta chain; complement C4-A proprotein; Acidic complement C4; Basic complement
C4; CH; Chido blood group; Complement component 4A; Complement component 4B;
RG; Rodgers blood group; CO4A_HUMAN; CO4B_HUMAN; C4A; C4; C4A2; C4A3; C4A4;
C4A6; C4AD; C4S; CO4; CPAMD2; RG.
研究領(lǐng)域；細(xì)胞生物 免疫學(xué)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
not yet tested in
other applications.
optimal dilutions/concentrations
should be determined by the end user.
理論分子量；72/190kDa
細(xì)胞定位；細(xì)胞膜 細(xì)胞外基質(zhì)
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human C4a and C4b Complement C4 beta
chain: 21-120/1744
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
This gene encodes the acidic form of complement
factor 4, part of the classical activation pathway. The protein is expressed
as a single chain precursor which is proteolytically cleaved into a trimer of
alpha, beta, and gamma chains prior to secretion. The trimer provides a
surface for interaction between the antigen-antibody complex and other
complement components. The alpha chain may be cleaved to release C4
anaphylatoxin, a mediator of local inflammation. Deficiency of this protein
is associated with systemic lupus erythematosus and type I diabetes mellitus.
This gene localizes to the major histocompatibility complex (MHC) class III
region on chromosome 6. Varying haplotypes of this gene cluster exist, such
that individuals may have 1, 2, or 3 copies of this gene. Two transcript
variants encoding different isoforms have been found for this gene. [provided
by RefSeq, Nov 2011]. Non-enzymatic component of C3 and C5 convertases
and thus essential for the propagation of the classical complement pathway.
Covalently binds to immunoglobulins and immune complexes and enhances the
solubilization of immune aggregates and the clearance of IC through CR1 on
erythrocytes. C4A isotype is responsible for effective binding to form amide
bonds with immune aggregates or protein antigens, while C4B isotype catalyzes
the transacylation of the thioester carbonyl group to form ester bonds with
carbohydrate antigens. Derived from proteolytic degradation of complement
C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces
the contraction of smooth muscle, increases vascular permeability and causes
histamine release from mast cells and basophilic leukocytes. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進平臺，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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