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簡要描述：L型電壓依賴型鈣通道β4抗體免 疫 原；KLH conjugated synthetic peptide derived from human CACNB4/L-type Ca++ CPβ4: 301-400/520
產(chǎn)品型號：GOY-01K1155廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問 量：137產(chǎn)品分類
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L型電壓依賴型鈣通道β4抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
L型電壓依賴型鈣通道β4抗體 | CACNB4 | GOY-01K1155 |
商品屬性：
英文名稱: CACNB4
中文名:L型電壓依賴型鈣通道β4抗體
別 名；CAB4; L-type Ca++
CPβ4; CACB4_HUMAN; Cacnb4; CACNLB4; Calcium channel
voltage dependent beta 4 subunit; Calcium channel voltage dependent subunit
beta 4; Calcium channel voltage-dependent subunit beta 4; Dihydropyridine
sensitive L type calcium channel beta 4 subunit; EA5; EIG9; EJM; EJM4;
Voltage-dependent L-type calcium channel subunit beta-4.
研究領(lǐng)域；細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 通道蛋白
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；58kDa
細(xì)胞定位；細(xì)胞漿 細(xì)胞膜
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human CACNB4/L-type Ca++ CPβ4: 301-400/520
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Voltage-dependent calcium channels are essential
for the release of neurotransmitters. L-type (long lasting current) voltage-dependent
calcium channels are composed of four subunits: an Alpha1 subunit, a Beta
subunit, a Beta subunit and an Alpha2 Gamma subunit. The Beta subunit is
encoded by four genes, designated Beta1-Beta 4, all of which contribute to
the diversity of calcium currents and are involved in membrane trafficking of
the Beta subunit. L-type Ca++ CP Beta 4, also known as CACNB4 (Calcium
channel voltage-dependent subunit beta 4), CACNLB4 or CAB4, is a 484 amino
acid protein that contains one SH3 domain and is expressed in ovary, brain
and smooth muscle. Functioning as one of the four components of the Beta
subunit, L-type Ca++ CP Beta 4 increases the peak calcium current in
voltage-dependent calcium channels, thereby shifting the voltage dependencies
of activation and inactivation and controlling G protein inhibition and Beta
membrane targeting. Two isoforms of L-type Ca++ CP Beta4 exist due to
alternative splicing events. The beta subunit of voltage-dependent calcium
channels contributes to the function of the calcium channel by increasing
peak calcium current, shifting the voltage dependencies of activation and
inactivation, modulating G protein inhibition and controlling the alpha-1
subunit membrane targeting. Subunit: The L-type calcium channel is composed of four
subunits: alpha-1, alpha-2, beta and gamma. Interacts with FASLG. Tissue Specificity: Expressed predominantly in the cerebellum and
kidney. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中，與客戶互動驗(yàn)證，確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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