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簡要描述：肌鈣集蛋白/收鈣素抗體免 疫 原；KLH conjugated synthetic peptide derived from human Calsequestrin: 75-170/396
產品型號：GOY-01K1983廠商性質：科研更新時間：2023-10-24 00:00:00訪 問 量：140產品分類
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肌鈣集蛋白/收鈣素抗體
產品名稱 | 英文名稱 | 貨號 |
肌鈣集蛋白/收鈣素抗體 | Calsequestrin | GOY-01K1983 |
商品屬性：
英文名稱: Calsequestrin
中文名:肌鈣集蛋白/收鈣素抗體
別 名；CASQ;
Calsequestrin 1; Calsequestrin 1 fast twitch skeletal muscle; Calsequestrin 2;
Calsequestrin 2 fast twitch cardiac muscle; Calsequestrin cardiac muscle
isoform; Calsequestrin skeletal muscle isoform; Cardiac calsequestrin 2; CASQ
1; CASQ 2; PDIB1; PDIB2; Skeletal muscle calsequestrin 1.
研究領域；心血管 信號轉導 轉錄調節(jié)因子 結合蛋白 線粒體
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應；(predicted:
Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, )
產品應用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；40kDa
細胞定位；細胞漿 線粒體
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human Calsequestrin: 75-170/396
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產品介紹:
The sarcoplasmic reticulum (SR) is, in part,
responsible for maintaining the level of intracellular calcium in cardiac and
skeletal muscle by storing and releasing calcium. Several intralumenal SR
calcium binding proteins have been identified, the most prominent of these is
calsequestrin. Calsequstrin is a calcium binding protein known to sequester
calcium accumulated in the sarcoplasmic reticulum of muscle cells during
relaxation and is found discretely localized to the junctional and corbular
(terminal cisternae) SR. Calsequestrin functions to localize calcium near the
junctional face of the terminal cisternae from which calcium can be released
into the cytosol via the ryanodine receptor. This protein is highly acidic
and has a large capacity and moderate to low affinity for calcium. Calsequestrin is a high-capacity, moderate
affinity, calcium-binding protein and thus acts as an internal calcium store
in muscle. The release of calcium bound to calsequestrin through a calcium
release channel triggers muscle contraction. The skeletal muscle isoform
(CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds
approximately 60 Ca(2+). |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結果是陽性。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應用驗證需求。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務，包含鼠源單克隆抗體構建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務，如動物免疫、動物飼養(yǎng)、抗體修飾服務（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務。
抗體定制服務:
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務，主要面向工業(yè)客戶。
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