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簡(jiǎn)要描述：原癌基因CBL2抗體免 疫 原；KLH conjugated synthetic peptide derived from human CBL: 241-340/906
產(chǎn)品型號(hào)：GOY-01K2750廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：113產(chǎn)品分類
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原癌基因CBL2抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
原癌基因CBL2抗體 | CBL | GOY-01K2750 |
商品屬性：
英文名稱: CBL
中文名:原癌基因CBL2抗體
別 名；C CBL; Cas-Br-M (murine)
ecotropic retroviral transforming sequence; Casitas B lineage lymphoma proto
oncogene; CBL 2; CBL2; E3 ubiquitin protein ligase CBL; Oncogene CBL2; Proto
oncogene c CBL; RGD1561386; RING finger protein 55; RNF55v Signal transduction
protein CBL; 4732447J05Rik; CBL_HUMAN.
研究領(lǐng)域；腫瘤 免疫學(xué) 染色質(zhì)和核信號(hào) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 生長(zhǎng)因子和激素 轉(zhuǎn)錄調(diào)節(jié)因子 細(xì)胞膜受體 b-淋巴細(xì)胞
抗體來(lái)源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；99kDa
細(xì)胞定位；細(xì)胞漿 細(xì)胞膜
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human CBL: 241-340/906
亞 型；IgG
純化方法；affinity
purified by Protein A
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
This gene is a proto-oncogene that encodes a RING
finger E3 ubiquitin ligase. The encoded protein is one of the enzymes
required for targeting substrates for degradation by the proteasome. This
protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes
(E2) to specific substrates. This protein also contains an N-terminal
phosphotyrosine binding domain that allows it to interact with numerous
tyrosine-phosphorylated substrates and target them for proteasome
degradation. As such it functions as a negative regulator of many signal
transduction pathways. This gene has been found to be mutated or translocated
in many cancers including acute myeloid leukaemia. Mutations in this gene are
also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar
2012] Function: Adapter protein that functions as a negative
regulator of many signaling pathways that are triggered by activation of cell
surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts
ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers
it to substrates promoting their degradation by the proteasome. Recognizes
activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2,
PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling.
Recognizes membrane-bound HCK and other kinases of the SRC family and
mediates their ubiquitination and degradation. Participates in signal
transduction in hematopoietic cells. Plays an important role in the
regulation of osteoblast differentiation and apoptosis. Essential for
osteoclastic bone resorption. The Tyr-731 phosphorylated form induces the
activation and recruitment of phosphatidylinositol 3-kinase to the cell
membrane in a signaling pathway that is critical for osteoclast function. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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