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簡(jiǎn)要描述：CD299抗體免 疫 原；KLH conjugated synthetic peptide derived from human CD299: 101-200/399
產(chǎn)品型號(hào)：GOY-01K2024廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問 量：148產(chǎn)品分類
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CD299抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
CD299抗體 | CD299 | GOY-01K2024 |
商品屬性：
英文名稱: CD299
中文名:CD299抗體
別 名；C type lectin
domain family 4 member M; C type lectin domain family 4, member M; C-type
lectin domain family 4, member M; CD209 antigen like protein 1; CD209
antigen-like; CD209L; CD209L1; CD299 antigen; CLEC4M; DC SIGN related protein;
DC SIGN2; DC SIGNR; DC-SIGN related protein; DC-SIGN2; DC-SIGNR; DCSIGN-related
protein; DCSIGNR; dendritic cell specific ICAM-3-grabbing nonintegrin 2;
Dendritic cell-specific ICAM-3-grabbing non-integrin 2; HP10347; L SIGN;
Liver/lymph node specific ICAM 3 grabbing nonintegrin; Liver/lymph
node-specific ICAM3-grabbing nonintegrin; LSIGN; Mannose binding C-type lectin
DC-SIGNR; MGC129964; MGC47866; CLC4M_HUMAN.
研究領(lǐng)域；細(xì)胞生物 免疫學(xué) 淋巴細(xì)胞
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；45kDa
細(xì)胞定位；細(xì)胞膜 分泌型蛋白
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human CD299: 101-200/399
<Extracellular>
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Dendritic cells (DC) play a primary role in the
immune system as antigen presenting cells. A key molecule, dendritic cell
specific ICAM3 grabbing nonintegrin (DC SIGN1), is involved in regulating
interactions between DC and resting T cells, including antigen presentation
to T cells and enhancement of transinfection of CD4+ T cells by HIV 1.
Efforts to identify additional type II membrane proteins resulted in the
isolation of a related molecule named CD299, also known as DC SIGNR (DC SIGN
Related), DC SIGN2, CD209L, and L SIGN (liver/lymph nodespecific ICAM3
grabbing nonintegrin). CD299 is located on Human chromosome 19p13.3 and
shares 73-80% amino acid identity with DC SIGN1. Its structure is similar to
DC SIGN1 and therefore binds mannose residues in a calcium dependent fashion,
including ICAM3 and HIV 1 gp120. CD299 is polymorphic, since allelic
variations of the exon 4 encoded sequence have been isolated. This is further
supported by a study demonstrating the ability to isolate a large repertoire
of CD299 transcripts largely the result of alternative splicing of the 7
coding exons. CD299 is primarily transcribed in the liver and lymph nodes but
not in monocyte derived DC. Expression of CD299 is restricted to endothelial
cells derived from liver sinusoids, lymph nodes sinuses, and capillaries,
although variable expression in placenta and some monocytic cell lines has
also been reported, including both membrane and soluble isoforms of the
protein. Function: Probable pathogen-recognition receptor involved in
peripheral immune surveillance in liver. May mediate the endocytosis of
pathogens which are subsequently degraded in lysosomal compartments. Probably
recognizes in a calcium-dependent manner high mannose N-linked
oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120,
HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS
coronavirus protein S. Is a receptor for ICAM3, probably by binding to mannose-like
carbohydrates. Is presumably a coreceptor for the SARS coronavirus. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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