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簡(jiǎn)要描述：CD2結(jié)合蛋白3抗體免 疫 原；KLH conjugated synthetic peptide derived from human SH3KBP1/CD2BP3: 591-665/665
產(chǎn)品型號(hào)：GOY-01K0945廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：149產(chǎn)品分類(lèi)
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CD2結(jié)合蛋白3抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
CD2結(jié)合蛋白3抗體 | CD2BP3 | GOY-01K0945 |
商品屬性：
英文名稱: CD2BP3
中文名:CD2結(jié)合蛋白3抗體
別 名；Cbl interacting
protein; Cbl interacting protein of 85 kDa; CD2 binding protein 3; CD2BP3; CIN
85; CIN85; GIG 10; GIG10; HSB 1; Human Src family kinase binding protein 1; MIG
18; MIG18; Migration inducing gene 18 protein; SH3 domain kinase binding
protein 1; SH3BP 1; Src family kinase binding protein 1; src related kinase
binding protein 1; SH3K1_HUMAN.
研究領(lǐng)域；腫瘤 信號(hào)轉(zhuǎn)導(dǎo)
抗體來(lái)源；Rabbit
克隆類(lèi)型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Cow, Rabbit, Sheep, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；73kDa
細(xì)胞定位；細(xì)胞漿 細(xì)胞膜
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human SH3KBP1/CD2BP3: 591-665/665
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
SH3KBP1 belongs to the CIN85/CMS family of adaptor
molecules, characterized by containing three N-terminal Src homology domains,
a proline rich region and a C-terminal coiled-coil domain. The different
members of the family orchestrate a network involved in dowregulation and
degradation of recpetor tyrosine kinases. SH3KBP1 is involved in regulating
diverse signal transduction pathways. Involved in the regulation of
endocytosis and lysosomal degradation of ligand-induced receptor tyrosine
kinases, including EGFR and MET/hepatocyte growth factor receptor, through a
association with CBL and endophilins. In the case of EGF receptor turnover,
its activation involves recruitment of SH3KBP1- endophilin complexes to
mediate internalization. Once internalized, RTKs are delivered into the
endosomal compartment where receptors get sorted for either recycling back to
the cell surface or are targeted to lysosomes for degradation. Alternate
splicing results in multiple transcript variants. Function: Adapter protein involved in regulating diverse
signal transduction pathways. Involved in the regulation of endocytosis and
lysosomal degradation of ligand-induced receptor tyrosine kinases, including
EGFR and MET/hepatocyte growth factor receptor, through a association with
CBL and endophilins. The association with CBL, and thus the receptor
internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2.
Involved in regulation of ligand-dependent endocytosis of the IgE receptor.
Attenuates phosphatidylinositol 3-kinase activity by interaction with its
regulatory subunit (By similarity). May be involved in regulation of cell
adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved
in the regulation of cellular stress response via the MAPK pathways through
its interaction with MAP3K4. Is involved in modulation of tumor necrosis
factor mediated apoptosis. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專(zhuān)業(yè)的建議。在制備過(guò)程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類(lèi)型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專(zhuān)業(yè)服務(wù)，主要面向工業(yè)客戶。
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