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簡(jiǎn)要描述：CGG結(jié)合蛋白1抗體免 疫 原；KLH conjugated synthetic peptide derived from human CGGBP1: 1-100/167
產(chǎn)品型號(hào)：GOY-01K1301廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問 量：109產(chǎn)品分類
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CGG結(jié)合蛋白1抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
CGG結(jié)合蛋白1抗體 | CGGBP1 | GOY-01K1301 |
商品屬性：
英文名稱: CGGBP1
中文名:CGG結(jié)合蛋白1抗體
別 名；20 kDa CGG
binding protein; 20 kDa CGG-binding protein; CGBP1_HUMAN; CGG binding protein
1; CGG triplet repeat binding protein 1; CGG triplet repeat-binding protein 1;
CGG-binding protein 1; CGGBP 1; CGGBP; Cggbp1; OTTHUMP00000213853;
OTTHUMP00000213877; p20 CGG binding protein; p20 CGGBP; p20 CGGBP DNA binding
protein; p20-CGGBP DNA-binding protein.
研究領(lǐng)域；細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 表觀遺傳學(xué)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Pig, Cow, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
not yet tested in
other applications.
optimal dilutions/concentrations
should be determined by the end user.
理論分子量；19kDa
細(xì)胞定位；細(xì)胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human CGGBP1: 1-100/167
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Fragile X syndrome is the most frequent form of
inherited mental retardation and is the result of transcriptional silencing
of the FMR1 (fragile X mental retardation) gene on the X chromosome. The FMR1
gene contains a distinct CpG dinucleotide repeat located in the 5’-untranslated region of the gene which, in fragile X
syndrome, is substantially amplified and subject to extensive methylation and
enhanced transcriptional silencing. CGGBP1 (CGG triplet repeat binding
protein 1), also known as CGGBP or p20-CGGBP, is a 167 amino acid nuclear
protein that influences FMR1 expression. Highly expressed in thymus,
placenta, lymph nodes, cerebral cortex and cerebellum, CGGBP1 binds to the 5’ (CGG)n-3’ repeat in the promotor of the
FMR1 gene and positively regulates expression of the FMR1 protein. Binding of
CGGBP1 to the FMR1 promoter is inhibited by cytosine-specific DNA methylation
of the protein binding motif, suggesting that CGGBP1 activity is silenced in
FMR1-affected individuals. Function: Binds to nonmethylated 5'-d(CGG)(n)-3'
trinucleotide repeats in the FMR1 promoter. May play a role in regulating
FMR1 promoter. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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