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簡要描述：脊索生成素樣蛋白1抗體免 疫 原；KLH conjugated synthetic peptide derived from human CHRDL1: 21-120/450
產(chǎn)品型號：GOY-01K0358廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：135產(chǎn)品分類
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脊索生成素樣蛋白1抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
脊索生成素樣蛋白1抗體 | CHRDL1 | GOY-01K0358 |
商品屬性：
英文名稱: CHRDL1
中文名:脊索生成素樣蛋白1抗體
別 名；CHL; chordin like
1; Chordin-like protein 1; CHRDL1; CRDL1_HUMAN; dA141H5.1; neuralin 1;
Neuralin-1; Neurogenesin-1; NRLN1; Ventroptin; VOPT.
研究領(lǐng)域；細胞生物 發(fā)育生物學 神經(jīng)生物學
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；49kDa
細胞定位；分泌型蛋白
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human CHRDL1: 21-120/450
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This product
as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The patterning of the central nervous system (CNS)
relies on the interaction of multiple signaling molecules, including Shh
(sonic hedgehog homolog), Wnt proteins and BMPs (bone morphogenetic
proteins), with their antagonists, namely chordin and Noggin. Chordin is a
key developmental protein that dorsalizes early vertebrate embryonic tissues
by binding to ventralizing TGF-beta-like BMPs and sequestering them in latent
complexes. CHRDL1 (Chordin-like protein 1), also known as CHL, VOPT
(Ventroptin) or NRLN1 (Neuralin-1), is a 450 amino acid secreted protein that
contains three VWFC domains. Functioning in a similar manner to chordin, CHRDL1
binds to BMP-4 and prevents the interaction of BMP-4 with its target
receptors, thereby antagonizing BMP-4 activity. Additionally, CHRDL1 is
thought to play a role in dorsoventral axis formation, embryonic bone
formation and angiogenesis, as well as in the differentiation of neural stem
cells. Antagonizes the function of BMP4 by binding to it
and preventing its interaction with receptors. Alters the fate commitment of
neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal
differentiation of neural stem cells in the brain by preventing the adoption
of a glial fate. May play a crucial role in dorsoventral axis formation. May
play a role in embyonic bone formation (By similarity). May also play an
important role in regulating retinal angiogenesis trough modulation of BMP4
actions in endothelial cells. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務(wù)。
單項免疫學及檢測服務(wù):
我公司也為客戶提供單項免疫學和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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