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簡要描述：16號染色體開放閱讀框41抗體免 疫 原；KLH conjugated synthetic peptide derived from human CHTF18/C16orf41: 301-400/975
產品型號：GOY-01K0417廠商性質：科研更新時間：2023-10-24 00:00:00訪 問 量：133產品分類
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16號染色體開放閱讀框41抗體
產品名稱 | 英文名稱 | 貨號 |
16號染色體開放閱讀框41抗體 | CHTF18 | GOY-01K0417 |
商品屬性：
英文名稱: CHTF18
中文名:16號染色體開放閱讀框41抗體
別 名；C16orf41;
6030457M03Rik; C16orf41; C321D2.2; C321D2.3; C321D2.4; CHL12; chromosome
transmission fidelity factor 18 homolog (S. cerevisiae); Chromosome
transmission fidelity protein 18 homolog; chtf18; Ctf18; CTF18_HUMAN; hCTF18;
MGC38008; RUVBL.
研究領域；細胞生物 染色質和核信號 細胞周期蛋白
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應；(predicted:
Human, Mouse, Rat, )
產品應用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；106kDa
細胞定位；細胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human CHTF18/C16orf41: 301-400/975
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產品介紹:
CTF18 is a 975 amino acid protein encoded by the
human gene CHTF18. CTF18 is a protein that is structurally related to the
Rad24 and RFC (replication factor C) proteins. CTF18 is believed to form a
novel RFC complex and functions redundantly with Rad24 in the DNA replication
block checkpoint. The CTF18-RFC complex is a seven-subunit structure that
consists of the four small subunits of RFC, together with CTF18, DCC1, and
CTF8. This RFC complex is responsible for loading the replication clamp PCNA
(Proliferating Cell Nuclear Antigen) onto DNA and functions in DNA
replication and repair. Regulated unloading of PCNA during the progression
and termination of DNA replication does not seem to be a function of the
CTF18-RFC complex. Function: Chromosome cohesion factor involved in sister
chromatid cohesion and fidelity of chromosome transmission. Component of one
of the cell nuclear antigen loader complexes, CTF18-replication factor C
(CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5.
The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak
ATPase activity that is stimulated by the presence of primed DNA, replication
protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The
CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and
gapped DNA. It also interacts with and stimulates DNA polymerase POLH. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結果是陽性。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應用驗證需求。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務，包含鼠源單克隆抗體構建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務，如動物免疫、動物飼養(yǎng)、抗體修飾服務（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務。
抗體定制服務:
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務，主要面向工業(yè)客戶。
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