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簡要描述：組織相容性復(fù)合體蛋白2反式激活因子抗體免 疫 原；KLH conjugated synthetic peptide derived from human CIITA: 701-800/1130
產(chǎn)品型號：GOY-01K0770廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：144產(chǎn)品分類
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組織相容性復(fù)合體蛋白2反式激活因子抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
組織相容性復(fù)合體蛋白2反式激活因子抗體 | CIITA | GOY-01K0770 |
商品屬性：
英文名稱: CIITA
中文名:組織相容性復(fù)合體蛋白2反式激活因子抗體
別 名；C2TA; C2TA_HUMAN;
CIITA; Ciita; CIITA IV; class II major histocompatibility complex
transactivator; class II transactivator; MHC class II transactivator; MHC class
II transactivator type III; MHC2TA; NLR family acid domain containing; NLRA;
Nucleotide binding oligomerization domain leucine rich repeat and acid domain
containing.
研究領(lǐng)域；細(xì)胞生物 神經(jīng)生物學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 淋巴細(xì)胞 表觀遺傳學(xué)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；123kDa
細(xì)胞定位；細(xì)胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human CIITA: 701-800/1130
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
This gene encodes a protein with an acidic transcriptional
activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain.
The protein is located in the nucleus and acts as a positive regulator of
class II major histocompatibility complex gene transcription, and is referred
to as the "master control factor" for the expression of these
genes. The protein also binds GTP and uses GTP binding to facilitate its own
transport into the nucleus. Once in the nucleus it does not bind DNA but
rather uses an intrinsic acetyltransferase (AT) activity to act in a
coactivator-like fashion. Mutations in this gene have been associated with
bare lymphocyte syndrome type II (also known as hereditary MHC class II
deficiency or HLA class II-deficient combined immunodeficiency), increased
susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly
myocardial infarction. [provided by RefSeq, Jul 2008] Function: Essential for transcriptional activity of the HLA
class II promoter; activation is via the proximal promoter. No DNA binding of
in vitro translated CIITA was detected. May act in a coactivator-like fashion
through protein-protein interactions by contacting factors binding to the
proximal MHC class II promoter, to elements of the transcription machinery,
or both. Alternatively it may activate HLA class II transcription by
modifying proteins that bind to the MHC class II promoter. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進(jìn)行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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