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簡要描述：常染色體隱性遺傳肝硬化1A抗體免 疫 原；KLH conjugated synthetic peptide derived from human Cirhin: 221-320/686
產品型號：GOY-01K1339廠商性質：科研更新時間：2023-10-24 00:00:00訪 問 量：130產品分類
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常染色體隱性遺傳肝硬化1A抗體
產品名稱 | 英文名稱 | 貨號 |
常染色體隱性遺傳肝硬化1A抗體 | Cirhin | GOY-01K1339 |
商品屬性：
英文名稱: Cirhin
中文名:常染色體隱性遺傳肝硬化1A抗體
別 名；CIRH1A; CIRH 1A;
Cirhin; Cirrhosis, autosomal recessive 1A (cirhin); FLJ17146; KIAA1988; NAIC;
testis expressed gene 292; TEX292; CIR1A_HUMAN.
研究領域；腫瘤 細胞生物 染色質和核信號 信號轉導 轉錄調節(jié)因子 細菌及病毒 表觀遺傳學
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應；(predicted:
Human, Rat, Dog, Horse, )
產品應用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；77kDa
細胞定位；細胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human Cirhin: 221-320/686
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產品介紹:
CIRH1A (cirrhosis, autosomal recessive 1A), also
designated cirhin, NAIC or TEX292, is a 686 amino acid protein that, when
mutated, causes a severe autosomal recessive intrahepatic cholestasis known
as North American Indian childhood cirrhosis (NAIC). NAIC is found in
aboriginal children from northwestern Quebec, and is characterized by
transient neonatal jaundice which progresses to biliary cirrhosis, portal
hypertension and periportal fibrosis during childhood and adolescence.
Localizing to nucleolus, CIRH1A contains eleven WD repeats, exists as three
alternatively spliced isoforms and is encoded by a gene that maps to human
chromosome 16q22.1. Chromosome 16 encodes over 900 genes in approximately 90
million base pairs, makes up nearly 3% of human cellular DNA and is
associated with a variety of genetic disorders. Defects in Cirhin are the cause of North American
Indian childhood cirrhosis. NAIC is a severe autosomal recessive intrahepatic
cholestasis, originally described in Ojibway-Cree children from northwestern
Quebec. NAIC typically presents with transient neonatal jaundice, in a child
who is otherwise healthy, and progresses to biliary cirrhosis and portal
hypertension. Biochemical and histopathological features suggest involvement
of the bile ducts rather than of the bile canaliculi. They include elevated
gamma glutamyltransferase and alkaline phosphatase levels, and, typically,
marked fibrosis around bile ducts. Clinically, NAIC is distinct from other
nonsyndromic familial cholestases because of its marked cholangiopathic
features and severe degree of fibrosis on liver histology. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結果是陽性。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應用驗證需求。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務，包含鼠源單克隆抗體構建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務，如動物免疫、動物飼養(yǎng)、抗體修飾服務（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務。
抗體定制服務:
已注冊商標，主要用于抗體藥物發(fā)現和開發(fā)，是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務，主要面向工業(yè)客戶。
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