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簡(jiǎn)要描述：鈣激活氯離子通道蛋白3抗體免 疫 原；KLH conjugated synthetic peptide derived from mouse CLCA3: 811-913/913
產(chǎn)品型號(hào)：GOY-01K4636廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：152產(chǎn)品分類
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鈣激活氯離子通道蛋白3抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
鈣激活氯離子通道蛋白3抗體 | CLCA3 | GOY-01K4636 |
商品屬性：
英文名稱: CLCA3
中文名:鈣激活氯離子通道蛋白3抗體
別 名；Calcium activated
chloride channel 3; Calcium-activated chloride channel regulator family member
3; Chloride channel accessory 3 pseudogene; chloride channel calcium activated
3; Chloride channel calcium activated family member 3; Clca1; Clca2; CLCA3P;
Gob 5; Gob-5; Gob5; hCLCA3; mCLCA3; MGC143984; MGC143985.
研究領(lǐng)域；腫瘤 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo)
抗體來(lái)源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Mouse, Rat, Dog, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；98kDa
細(xì)胞定位；細(xì)胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from mouse CLCA3: 811-913/913
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The calcium-activated chloride channel (CLCA)
protein family, which includes the human homologs CLCA1 and CLCA2, display
distinct tissue distribution patterns. CLCA1 is expressed as a precursor
protein that is processed into two cell surface associated subunits and a
group of proteins. CLCA1 is upregulated by interleukin-9 and regulates the
expression of mucins. CLCA1 may provide a therapeutic target to control mucus
overproduction in airway disease patients with cystic fibrosis. CLCA2
expression is downregulated in breast cancer, therefore CLCA2 is thought to
act as a tumor suppressor in normal cells. CLCA3 (known as Clca3 in mouse) is
a structurally divergent member of the CLCA family that does not function as
a channel protein. CLCA4 is a CLCA member that is expressed in human rectal
mucosa, CLCA5 shows strong expression in eye and spleen, and CLCA6 is
primarily expressed in intestine and stomach. mCLCA3 (alias gob-5) is the third murine member of
the family of calcium-activated chloride channels (CLCA-family). mCLCA3 plays
a role in diseases with secretory dysfunctions, including asthma and cystic
fibrosis. The mCLCA3 protein is located in mucin granule membranes of goblet
cells of the intestinal, respiratory and reproductive tracts. It is also
secreted into the mucin layer on mucosal membranes. The protein appears to be
involved in the synthesis, condensation or secretion of mucins. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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