簡(jiǎn)要描述:氯離子通道KB抗體免 疫 原;KLH conjugated synthetic peptide derived from human CLCNKB: 51-150/687
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氯離子通道KB抗體
產(chǎn)品名稱(chēng) | 英文名稱(chēng) | 貨號(hào) |
氯離子通道KB抗體 | CLCNKB | GOY-01K1253 |
商品屬性:
英文名稱(chēng): CLCNKB
中文名:氯離子通道KB抗體
別 名;Bartter syndrome
type 3; Chloride channel Kb; Chloride channel kidney B; Chloride channel
protein ClC-Kb; Chloride channel voltage sensitive Kb; ClC K2; ClC-K2; ClCK2; CLCKB;
CLCKB_HUMAN; CLCNKB; hClC Kb; hClCKb; MGC24087; OTTHUMP00000011120;
OTTHUMP00000011121; RP11 5P18.8.
研究領(lǐng)域;腫瘤 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 通道蛋白
抗體來(lái)源;Rabbit
克隆類(lèi)型;Polyclonal
交叉反應(yīng);(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用;ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;75kDa
細(xì)胞定位;細(xì)胞膜
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human CLCNKB: 51-150/687
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng);This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The family of voltage-dependent chloride channels
(CLCs) regulate cellular trafficking of chloride ions, a critical component
of all living cells. CLCs regulate excitability in muscle and nerve cells,
aid in organic solute transport, and maintain cellular volume. CLC-KA is a
kidney-specific chloride channel that mediates transepithelial chloride
transport in the thin ascending limb of the Henle loop in the inner medulla.
CLC-KA plays a crucial role in urine concentration. The gene encoding human
CLC-KA maps to chromosome 1p36. Mutations in this gene may be associated with
nephrogenic diabetes insipidus in those cases where mutations in the
vasopressin V2 receptor and the AQP2 water channel are lacking. CLC-KB
mediates basolateral chloride ion efflux in the thick ascending limb and in
more distal nephron segments. The gene encoding human CLC-KB maps to
chromosome 1p36. Mutations in this gene cause type III Barter’s syndrome which is characterized by renal
salt-wasting and low blood pressure. Voltage-gated chloride channel. Chloride channels
have several functions including the regulation of cell volume; membrane
potential stabilization, signal transduction and transepithelial transport.
May be important in urinary concentrating mechanisms. |
多克隆抗體制備:
我公司合成抗原,保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1:32000,由蛋白抗原制備的多抗,保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶(hù)節(jié)約成本。
鼠單克隆抗體制備:
客戶(hù)可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行,我公司將為您的項(xiàng)目提供專(zhuān)業(yè)的建議。在制備過(guò)程中,與客戶(hù)互動(dòng)驗(yàn)證,確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí),也能滿(mǎn)足客戶(hù)抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶(hù)節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái),能為客戶(hù)提供各種類(lèi)型的重組抗體表達(dá)服務(wù),包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá),抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶(hù)提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù),如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)(如FITC,HRP等的標(biāo)記)、以及ELISA,WB,IHC,DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo),主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā),是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶(hù)量身定制的專(zhuān)業(yè)服務(wù),主要面向工業(yè)客戶(hù)。
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