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簡要描述：環(huán)核苷酸門控陽離子通道蛋白β3/CNG-β3抗體免 疫 原；KLH conjugated synthetic peptide derived from human CNGB3: 301-400/809
產(chǎn)品型號：GOY-01K2676廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：136產(chǎn)品分類
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環(huán)核苷酸門控陽離子通道蛋白β3/CNG-β3抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
環(huán)核苷酸門控陽離子通道蛋白β3/CNG-β3抗體 | CNGB3 | GOY-01K2676 |
商品屬性：
英文名稱: CNGB3
中文名:環(huán)核苷酸門控陽離子通道蛋白β3/CNG-β3抗體
別 名；ACHM1; ACHM3;
Achromatopsia (rod monochromacy) 3; CNG channel beta-3; CNGB3; CNGB-3_HUMAN;
Cone photoreceptor cGMP-gated cation channel beta-subunit; Cone photoreceptor
cGMP-gated channel subunit beta; Cyclic nucleotide gated channel beta 3; Cyclic
nucleotide-gated cation channel beta-3; Cyclic nucleotide-gated cation channel
modulatory subunit; Cyclic nucleotide-gated channel beta-3; RMCH; RMCH1.
研究領(lǐng)域；細胞生物 神經(jīng)生物學 通道蛋白 細胞膜受體
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；92kDa
細胞定位；細胞膜
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human CNGB3: 301-400/809
<Extracellular>
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Cyclic nucleotide-gated (CNG) cation channels are heteromeric
complexes made up of principal alpha and modulatory beta subunits. The alpha
subunits consist of CNG1-3 and form functional cation channels by themselves.
The beta subunits consist of CNG4-6 and, unlike the alpha subunits, do not
form functional channels, but rather modify the properties of channels.
formed by CNG1-3. CNG channels are essential components of olfactory and
visual transduction. CNG proteins are present in cone and rod photoreceptors
and in the pineal gland, and they contribute to modulating arterial blood
pressure. CNG6, also designated cyclic-nucleotide-gated cation channel beta 3
(CNG-beta 3), is an integral membrane protein that can form a
heterooligomeric complex with CNG-3. CNG-beta 3 is activated by cGMP and this
activation leads to the depolarization of rod photoreceptors as a result of
cation channel being opened. CNG-beta 3 is expressed in a small group of
retinal photoreceptor cells and in testis. Mutations in the gene encoding for
CNG-beta 3, can cause achromatopsia, an autosomal recessively inherited
disease characterized by low visual acuity, photophobia, a lack of color
discrimination, and nystagmus. Visual signal transduction is mediated by a
G-protein coupled cascade using cGMP as second messenger. This protein can be
activated by cGMP which leads to an opening of the cation channel and thereby
causing a depolarization of rod photoreceptors. Induced a flickering channel
gating, weakened the outward rectification in the presence of extracellular
calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP
efficiency of the channel when coexpressed with CNGA3 (By similarity).
Essential for the generation of light-evoked electrical responses in the
red-, green- and blue sensitive cones. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務(wù)。
單項免疫學及檢測服務(wù):
我公司也為客戶提供單項免疫學和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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