簡要描述:肌動(dòng)蛋白結(jié)合蛋白1B抗體免 疫 原;KLH conjugated synthetic peptide derived from human CORO1B: 301-400/489
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肌動(dòng)蛋白結(jié)合蛋白1B抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
肌動(dòng)蛋白結(jié)合蛋白1B抗體 | CORO1B | GOY-01K0449 |
商品屬性:
英文名稱: CORO1B
中文名:肌動(dòng)蛋白結(jié)合蛋白1B抗體
別 名;COR1B_HUMAN; CORO
1B; CORO1B; Coronin 1B; Coronin 2; Coronin actin binding protein 1B;
Coronin-1B; Coronin-2; Coronin1B; Coronin2; DKFZP762I166; OTTHUMP00000236823.
研究領(lǐng)域;心血管 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 細(xì)胞骨架
抗體來源;Rabbit
克隆類型;Polyclonal
交叉反應(yīng);(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用;WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;54kDa
細(xì)胞定位;細(xì)胞漿
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human CORO1B: 301-400/489
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng);This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Coronins are a family of WD repeat-containing,
actin-binding proteins that localize to submembraneous areas and regulate
cell motility and cytoskeletal rearrangement. Coronin 1A (CORO1A, CLIPINA,
CLABP, TACO, p57) can form coiled coil-mediated homotrimeric complexes that
influence early phagosome formation. PKC-dependent phosphorylation of Coronin
1B (CORO1B) at Serine 2 regulates leading edge dynamics and cell motility in
fibroblasts through interactions with Arp2/3 complex. Coronin 1C (CORO1C,
Coronin 3, HCRNN4) is abundant in differentiating Neuro-2a cells, PC-12 cells
and primary oligodendrocytes, where it is thought to influence neuron
morphogenesis and migration. Coronin 2A (CORO2A, CLIPINB, IR10, WDR2) is a
component of the approximately 1.5-2 megadalton N-CoR (nuclear receptor
corepressor) complex of 10-12 proteins, which recruits HDACs to generate
repressive chromatin. Coronin 7 (CORO7, CRN7) localizes to the Golgi membrane
and influences the organization of intracellular membrane compartments and
vesicular trafficking. Coronin 2B (CORO2B, CLIPINC) and Coronin 6 (CORO6) are
similar to other members of this family, since they possess a conserved basic
N-terminal motif and 3-10 WD repeats clustered in one to two core domains. Regulates leading edge dynamics and cell motility
in fibroblasts. May be involved in cytokinesis and signal transduction. |
多克隆抗體制備:
我公司合成抗原,保證陽性血清和抗體ELISA效價(jià)達(dá)到1:32000,由蛋白抗原制備的多抗,保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行,我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中,與客戶互動(dòng)驗(yàn)證,確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時(shí),也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺,能為客戶提供各種類型的重組抗體表達(dá)服務(wù),包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá),抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測服務(wù),如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)(如FITC,HRP等的標(biāo)記)、以及ELISA,WB,IHC,DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo),主要用于抗體藥物發(fā)現(xiàn)和開發(fā),是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù),主要面向工業(yè)客戶。
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