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簡要描述：剪切和多聚腺苷酸化特異性因子73蛋白抗體免 疫 原；KLH conjugated synthetic peptide derived from human CPSF73: 51-150/684
產(chǎn)品型號(hào)：GOY-01K0437廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問 量：135產(chǎn)品分類
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剪切和多聚腺苷酸化特異性因子73蛋白抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
剪切和多聚腺苷酸化特異性因子73蛋白抗體 | CPSF73 | GOY-01K0437 |
商品屬性：
英文名稱: CPSF73
中文名:剪切和多聚腺苷酸化特異性因子73蛋白抗體
別 名；Cleavage and
polyadenylation specific factor 3 73kDa; Cleavage and polyadenylation
specificity factor 73 kDa subunit; Cleavage and polyadenylation specificity
factor subunit 3; CPSF 73; CPSF 73 kDa subunit; CPSF; CPSF-73; cpsf3;
CPSF3_HUMAN; CPSF73; YSH1.
研究領(lǐng)域；細(xì)胞生物 結(jié)合蛋白 表觀遺傳學(xué)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；77kDa
細(xì)胞定位；細(xì)胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human CPSF73: 51-150/684
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
This gene encodes a member of the
metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the
cleavage and polyadenylation specificity factor and functions as an
endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to
polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during
histone 3'-end pre-mRNA processing. [provided by RefSeq, Oct 2012] Component of the cleavage and polyadenylation
specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end
formation, recognizing the AAUAAA signal sequence and interacting with
poly(A) polymerase and other factors to bring about cleavage and poly(A)
addition. Has endonuclease activity, and functions as mRNA 3'-end-processing
endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7
snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage
of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the
subsequent downstream cleavage product (DCP) of mature histone mRNAs.
Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA
leaving a 3'hydroxyl group on the upstream fragment containing the stem loop
(SL) and 5' phosphate on the downstream cleavage product (DCP) starting with
CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive
and degrades the DCP RNA substrate even after complete removal of the
U7-binding site. Binds to the downstream cleavage product (DCP) of histone
pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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