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簡要描述：環(huán)腺苷酸應(yīng)答元件結(jié)合蛋白樣蛋白2抗體免 疫 原；KLH conjugated synthetic peptide derived from human CREBL2: 9-80/120
產(chǎn)品型號：GOY-01K4703廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：145產(chǎn)品分類
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環(huán)腺苷酸應(yīng)答元件結(jié)合蛋白樣蛋白2抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
環(huán)腺苷酸應(yīng)答元件結(jié)合蛋白樣蛋白2抗體 | CREBL2 | GOY-01K4703 |
商品屬性：
英文名稱: CREBL2
中文名:環(huán)腺苷酸應(yīng)答元件結(jié)合蛋白樣蛋白2抗體
別 名；cAMP responsive
element binding protein like 2; CREBL 2; MGC117311; MGC138362; MHBs-binding
protein 1; CRBL2_HUMAN.
研究領(lǐng)域；腫瘤 細胞生物 染色質(zhì)和核信號 信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；14kDa
細胞定位；細胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human CREBL2: 9-80/120
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
cAMP response element (CRE)-binding protein-like-2
(CREBL2) was identified in a search to find genes in a commonly deleted
region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently
associated with hematopoietic malignancies, as well as breast, non-small-cell
lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding
protein (CREB) over a 48-base long region which encodes the bZip domain of
CREB. The bZip domain consists of about 30 amino acids rich in basic residues
involved in DNA binding, followed by a leucine zipper motif involved in
protein dimerization. This suggests that CREBL2 encodes a protein with DNA
binding capabilities. The occurance of CREBL2 deletion in malignancy suggests
that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul
2008] CREBL2 is frequently associated with hematopoietic
malignancies, as well as breast, non-small-cell lung and ovarian cancers.
CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base
long region which encodes the bZip domain of CREB. The bZip domain consists
of about 30 amino acids rich in basic residues involved in DNA binding,
followed by a leucine zipper motif involved in protein dimerization. This
suggests that CREBL2 encodes a protein with DNA binding capabilities. The
occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a
tumor suppressor gene. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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