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簡(jiǎn)要描述：腫瘤/睪丸抗原27抗體（高遷移率族蛋白）免 疫 原；KLH conjugated synthetic peptide derived from human BORIS/CT27: 351-450/663
產(chǎn)品型號(hào)：GOY-01K1460廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：133產(chǎn)品分類
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腫瘤/睪丸抗原27抗體（高遷移率族蛋白）
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
腫瘤/睪丸抗原27抗體（高遷移率族蛋白） | CT27 | GOY-01K1460 |
商品屬性：
英文名稱: CT27
中文名:腫瘤/睪丸抗原27抗體（高遷移率族蛋白）
別 名；BORIS like
protein; Brother of the regulator of imprinted sites; Cancer/testis antigen 27;
CCCTC binding factor (zinc finger protein) like; CCCTC-binding factor; CT27;
CTCF paralog; CTCF T; CTCF-like protein; CTCFL; CTCFL_HUMAN; HMG 1L1; HMGB1L1;
Putative high mobility group protein 1 like 1; Putative high mobility group
protein B1 like 1; Transcriptional repressor CTCFL; Zinc finger protein CTCF-T.
研究領(lǐng)域；腫瘤 免疫學(xué) 染色質(zhì)和核信號(hào) 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子
抗體來(lái)源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；72kDa
細(xì)胞定位；細(xì)胞核 細(xì)胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human BORIS/CT27: 351-450/663
亞 型；IgG
純化方法；affinity purified
by Protein A
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Testis-specific DNA binding protein responsible
for insulator function, nuclear architecture and transcriptional control,
which probably acts by recruiting epigenetic chromatin modifiers. Plays a key
role in gene imprinting in male germline, by participating in the establishment
of differential methylation at the IGF2/H19 imprinted control region (ICR).
Directly binds the unmethylated H19 ICR and recruits the PRMT7
methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2.
This probably leads to recruit de novo DNA methyltransferases at these sites
(By similarity). Seems to act as tumor suppressor. In association with DNMT1
and DNMT3B, involved in activation of BAG1 gene expression by binding to its
promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and
BRCA1 promoters. Function: Testis-specific DNA binding protein responsible
for insulator function, nuclear architecture and transcriptional control,
which probably acts by recruiting epigenetic chromatin modifiers. Plays a key
role in gene imprinting in male germline, by participating in the
establishment of differential methylation at the IGF2/H19 imprinted control
region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7
methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2.
This probably leads to recruit de novo DNA methyltransferases at these sites
(By similarity). Seems to act as tumor suppressor. In association with DNMT1
and DNMT3B, involved in activation of BAG1 gene expression by binding to its
promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and
BRCA1 promoters. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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