簡(jiǎn)要描述:DHX58蛋白抗體免 疫 原;KLH conjugated synthetic peptide derived from human DHX58: 581-678/678
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DHX58蛋白抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
DHX58蛋白抗體 | DHX58 | GOY-01K0413 |
商品屬性:
英文名稱: DHX58
中文名:DHX58蛋白抗體
別 名;D11LGP2;
D11lgp2e; DEXH (Asp Glu X His) box polypeptide 58; DEXH box polypeptide 58; DHX
58; DHX58; DHX58_HUMAN; LGP 2; LGP2; Ortholog of mouse D11lgp2; Probable ATP
dependent helicase LGP2; Probable ATP dependent RNA helicase DHX58; Probable
ATP-dependent helicase LGP2; Probable ATP-dependent RNA helicase DHX58; Protein
D11Lgp2 homolog; RIG-I-like receptor LGP2; RLR; RNA helicase LGP2.
研究領(lǐng)域;免疫學(xué) 細(xì)菌及病毒 表觀遺傳學(xué)
抗體來(lái)源;Rabbit
克隆類型;Polyclonal
交叉反應(yīng);(predicted:
Human, Mouse, Rat, )
產(chǎn)品應(yīng)用;WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;77kDa
細(xì)胞定位;細(xì)胞漿
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human DHX58: 581-678/678
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件;Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng);This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
DHX58, is a 678 amino acid protein belonging to
the helicase family. LGP2 acts as a negative regulator of host innate immune
defense against viruses by binding dsRNA produced during viral replication.
The repressor domain of LGP2 binds to RIG-I, a signaling protein involved in
host defenses against hepatitis C virus (HCV). By preventing RIG-I
multimerization, LGP2 negatively regulates RIG-I-mediated signaling.
Localized to the cytoplasm, LGP2 contains one helicase ATP-binding domain and
one helicase C-terminal domain. Function: Participates in innate immune defense against
viruses. Upon interaction with intracellular dsRNA produced during viral
replication, triggers a transduction cascade which results in the induction
and expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). The
RNA helicase domain may recognize and structurally modify viral RNA to
facilitate detection by DDX58/RIG-I or by IFIH1/MDA5 whose affinity for dsRNA
is lower. |
多克隆抗體制備:
我公司合成抗原,保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1:32000,由蛋白抗原制備的多抗,保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行,我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中,與客戶互動(dòng)驗(yàn)證,確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí),也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái),能為客戶提供各種類型的重組抗體表達(dá)服務(wù),包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá),抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù),如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)(如FITC,HRP等的標(biāo)記)、以及ELISA,WB,IHC,DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo),主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā),是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù),主要面向工業(yè)客戶。
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