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簡(jiǎn)要描述：有絲分裂控制蛋白dis3抗體免 疫 原；KLH conjugated synthetic peptide derived from human DIS3: 701-800/958
產(chǎn)品型號(hào)：GOY-01K2872廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：123產(chǎn)品分類(lèi)
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有絲分裂控制蛋白dis3抗體
產(chǎn)品名稱(chēng) | 英文名稱(chēng) | 貨號(hào) |
有絲分裂控制蛋白dis3抗體 | DIS3 | GOY-01K2872 |
商品屬性：
英文名稱(chēng): DIS3
中文名:有絲分裂控制蛋白dis3抗體
別 名；Dis3; DIS3
mitotic control homolog (S. cerevisiae); dis3p; Exosome complex exonuclease
RRP44; Mitotic control protein dis3 homolog; Protein DIS3 homolog; Ribosomal
RNA processing protein 44; Ribosomal RNA-processing protein 44; RRP44;
RRP44_HUMAN.
研究領(lǐng)域；細(xì)胞生物 細(xì)胞周期蛋白 細(xì)胞分化 表觀遺傳學(xué)
抗體來(lái)源；Rabbit
克隆類(lèi)型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Dog, Horse, Rabbit, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；105kDa
細(xì)胞定位；細(xì)胞核 細(xì)胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH conjugated
synthetic peptide derived from human DIS3: 701-800/958
亞 型；IgG
純化方法；affinity
purified by Protein A
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Component of the exosome that has both 3'-5'
exonuclease and endonuclease activities. Required for the 3'-processing of
the 7S pre-RNA to the mature nuclear complex. As part of nucleoplasmic and
probably cytoplasmic forms of the RNA exosome complex, it is involved in RNA
processing and turnover. Also associated with the GTPase RAN. Function: Putative catalytic component of the RNA exosome
complex which has 3'->5' exoribonuclease activity and participates in a
multitude of cellular RNA processing and degradation events. In the nucleus,
the RNA exosome complex is involved in proper maturation of stable RNA
species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing
by-products and non-coding 'pervasive' transcripts, such as antisense RNA
species and promoter-upstream transcripts (PROMPTs), and of mRNAs with
processing defects, thereby limiting or excluding their export to the
cytoplasm. The RNA exosome may be involved in Ig class switch recombination
(CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting
AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm,
the RNA exosome complex is involved in general mRNA turnover and specifically
degrades inherently unstable mRNAs containing AU-rich elements (AREs) within
their 3' untranslated regions, and in RNA surveillance pathways, preventing
translation of aberrant mRNAs. It seems to be involved in degradation of
histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶(hù)節(jié)約成本。
鼠單克隆抗體制備:
客戶(hù)可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專(zhuān)業(yè)的建議。在制備過(guò)程中，與客戶(hù)互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶(hù)抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶(hù)節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶(hù)提供各種類(lèi)型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶(hù)提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶(hù)量身定制的專(zhuān)業(yè)服務(wù)，主要面向工業(yè)客戶(hù)。
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