簡要描述:減數(shù)分裂同源蛋白DMC1抗體免 疫 原;KLH conjugated synthetic peptide derived from human DMC1: 251-340/340
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減數(shù)分裂同源蛋白DMC1抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
減數(shù)分裂同源蛋白DMC1抗體 | DMC1 | GOY-01K2364 |
商品屬性:
英文名稱: DMC1
中文名:減數(shù)分裂同源蛋白DMC1抗體
別 名;disrupted meiotic
cDNA 1 homolog; dJ199H16.1; DMC 1; DMC1 dosage suppressor of mck1 homolog; DMC1
dosage suppressor of mck1 homolog meiosis specific homologous recombination
(yeast); DMC1 homologue; DMC1H; HsLim15; LIM15; Meiotic recombination protein
DMC1/LIM15 homolog; MGC150472; MGC150473; DMC1_HUMAN.
研究領(lǐng)域;腫瘤 細(xì)胞分化 表觀遺傳學(xué)
抗體來源;Rabbit
克隆類型;Polyclonal
交叉反應(yīng);(predicted:
Human, Mouse, Rat, Chicken, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用;WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;38kDa
細(xì)胞定位;細(xì)胞核
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human DMC1: 251-340/340
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng);This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
DNA repair proteins are necessary for the
maintenance of chromosome integrity and are involved in the elimination of
premutagenic lesions from DNA. The DNA repair proteins Rad51 and Rad52 are
key components of the double-strand-break repair (DSBR) pathway. Rad51 is
essential for mitotic and meiotic recombination, and its mutation in yeast
and mammalian cells results in chromosome loss. Overexpression of Rad52 confers
resistance to ionizing radiation and induces homologous intrachromosomal
recombination. Rad52 is thought to be involved in an early stage of
Rad51-mediated recombination. Additional proteins involved in the pathway
include Nibrin and Dmc1. Nibrin, which complexes with Mre11 and Rad50, is
absent in Nijemegen breakage syndrome (NBS) patients. Dmc1 is specifically
involved in meiotic recombination. An alternative spliced form of Dmc1,
designated Dmc1-D, is deleted for a region between the two motifs involved in
nucleotide binding. The alternatively spliced Dmc1-D transcript is detected
in both male and female germ cells, indicating that the encoded protein may
have a role in mammalian genetic recombination in meiosis. May participate in meiotic recombination,
specifically in homologous strand assimilation, which is required for the
resolution of meiotic double-strand breaks (By similarity). |
多克隆抗體制備:
我公司合成抗原,保證陽性血清和抗體ELISA效價(jià)達(dá)到1:32000,由蛋白抗原制備的多抗,保證WB檢測(cè)結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行,我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中,與客戶互動(dòng)驗(yàn)證,確保最終制備的抗體ELISA陽性血清檢測(cè)達(dá)到合同要求的同時(shí),也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái),能為客戶提供各種類型的重組抗體表達(dá)服務(wù),包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá),抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù),如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)(如FITC,HRP等的標(biāo)記)、以及ELISA,WB,IHC,DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo),主要用于抗體藥物發(fā)現(xiàn)和開發(fā),是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù),主要面向工業(yè)客戶。
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