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簡要描述：牙本質基質蛋白1抗體免 疫 原；KLH conjugated synthetic peptide derived from human DMP1: 221-320/513
產品型號：GOY-01K2035廠商性質：科研更新時間：2023-10-24 00:00:00訪 問 量：103產品分類
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牙本質基質蛋白1抗體
產品名稱 | 英文名稱 | 貨號 |
牙本質基質蛋白1抗體 | DMP1 | GOY-01K2035 |
商品屬性：
英文名稱: DMP1
中文名:牙本質基質蛋白1抗體
別 名；ARHP; ARHR;
AV020965; Dentin matrix acidic phosphoprotein 1; Dentin matrix protein 1;
DENTMAT; DMP 1; Dmp; MGC130441; PP; Serine rich acidic phosphoprotein;
DMP1_HUMAN.
研究領域；細胞生物 發(fā)育生物學 信號轉導 干細胞 細胞骨架
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應；(predicted:
Human, )
產品應用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；54kDa
細胞定位；細胞核 細胞漿 細胞外基質 分泌型蛋白
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human DMP1: 221-320/513
亞 型；IgG
純化方法；affinity
purified by Protein A
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產品介紹:
DMP-1 is a member of the small integrin ligand
N-linked glycoprotein family. It is important for the mineralization of bone
and dentin. DMP-1 is expressed in bone, tooth and hypertrophic cartilage. It
is synthesized by preosteoblasts and contains a large number of acidic
domains. DMP-1 localizes to the nucleus of undifferentiated osteoblasts where
it functions as a transcriptional regulator for osteoblast-specific gene
activation and induces osteoblast differentiation. During osteoblast
maturation, DMP-1 undergoes a conformational change and becomes
phosphorylated by casein kinase II in response to an influx of calcium ions
to the nucleus. DMP-1 is then exported to the extracellular matrix (ECM)
where it regulates the nucleation of hydroxyapatite and the formation of
calcified tissue. DMP-1 is proteolytically processed into N- and C-terminal
fragments in the ECM of bone and dentin. The protein has also been identified
in bone as a high molecular weight proteoglycan comprised of the N-terminal
DMP-1 fragment and chondroitin sulfate.The loss of DMP-1 can result in
hypomineralized bone. Function: DMP1 is an extracellular matrix protein and a
member of the small integrin binding ligand N-linked glycoprotein family. It
is critical for proper mineralization of bone and dentin, and is present in
diverse cells of bone and tooth tissues. DMP1 contains a large number of
acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell
attachment sequence, and a DNA binding domain. DMP1 may also have a dual
function during osteoblast differentiation. In the nucleus of undifferentiated
osteoblasts the unphosphorylated form acts as a transcriptional component for
activation of osteoblast-specific genes like osteocalcin. During the
osteoblast to osteocyte transition phase it is phosphorylated and exported
into the extracellular matrix, where it regulates nucleation of
hydroxyapatite. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結果是陽性。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應用驗證需求。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務，包含鼠源單克隆抗體構建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務，如動物免疫、動物飼養(yǎng)、抗體修飾服務（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務。
抗體定制服務:
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務，主要面向工業(yè)客戶。
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