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簡(jiǎn)要描述：DOCK10蛋白抗體免 疫 原；KLH conjugated synthetic peptide derived from human DOCK10: 4-100/186
產(chǎn)品型號(hào)：GOY-01K2485廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：182產(chǎn)品分類
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DOCK10蛋白抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
DOCK10蛋白抗體 | DOCK10 | GOY-01K2485 |
商品屬性：
英文名稱: DOCK10
中文名:DOCK10蛋白抗體
別 名；9330153B10Rik;
A630054M16Rik; dedicator of cytokinesis 10; Dedicator of cytokinesis protein
10; DKFZp781A1532; DRIP2; Jr4; Jr5; KIAA0694; MGC183664; mKIAA0694; Nbla10300;
R75174; ZIZ3; Zizimin 3.
研究領(lǐng)域；細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) G蛋白信號(hào)
抗體來(lái)源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Pig, )
產(chǎn)品應(yīng)用；IHC-P=1:100-500
IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；250kDa
細(xì)胞定位；細(xì)胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human DOCK10: 4-100/186
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
DOCK 10 is a 2,183 amino acid protein that belongs
to the DOCK family of cytokinesis-regulating proteins and cotnains one PH
domain, one DHR-1 domain and one DHR-2 domain. Expressed at lower levels in
lung and brain tissue, DOCK 10 functions as a potential GEF (guanine nucleotide
exchange factor) that is able to activate target GTPases by exchanging bound
GDP for free GTP. Multiple isoforms of DOCK 10 exist due to alternative
splicing events. The gene encoding DOCK 10 maps to human chromosome 2, which
houses over 1,400 genes and comprises nearly 8% of the human genome.
Harlequin icthyosis, a rare and morbid skin deformity, is associated with
mutations in the ABCA12 gene, while the lipid metabolic disorder
sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes. Additionally,
an extremely rare recessive genetic disorder, Alstr鰉 syndrome, is caused by mutations in the ALMS1 gene,
which maps to chromosome 2. Function: DOCK10 is a potential guanine nucleotide exchange
factor (GEF). GEF proteins activate some small GTPases by exchanging bound
GDP for free GTP. Two named isoforms exist, produced by alternative splicing. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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