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簡要描述：轉(zhuǎn)錄共激活因子130抗體免 疫 原；KLH conjugated synthetic peptide derived from human DRIP130/CRSP130: 401-500/1368
產(chǎn)品型號：GOY-01K0651廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：129產(chǎn)品分類
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轉(zhuǎn)錄共激活因子130抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
轉(zhuǎn)錄共激活因子130抗體 | DRIP130 | GOY-01K0651 |
商品屬性：
英文名稱: DRIP130
中文名:轉(zhuǎn)錄共激活因子130抗體
別 名；130 kDa
transcriptional co activator; 133 kDa transcriptional co activator; Activator
recruited cofactor 130 kDa component; Activator-recruited cofactor 130 kDa
component; ARC 130; ARC130; Cofactor required for Sp1 transcriptional activation
subunit 3 130kDa; Cofactor required for Sp1 transcriptional activation subunit
3 130kDa mediator; Cofactor required for Sp1 transcriptional activation subunit
3; CRSP 130; CRSP 130 kD subunit; CRSP 133; CRSP 3; CRSP complex subunit 3;
CRSP130; CRSP133; CRSP3; CRSP3 protein; DKFZp434H0117; DRIP 130; DRIP130;
hSur-2; KIAA1216; MED 23; MED23; MED23_HUMAN; Mediator complex subunit 23;
Mediator of RNA polymerase II transcription subunit 23; Protein sur-2 homolog;
SUR 2; SUR2; Transcriptional co activator CRSP 130; Transcriptional co
activator CRSP130; Transcriptional coactivator CRSP130; Vitamin D3 receptor
interacting protein; Vitamin D3 receptor interacting protein complex 130 kDa
component; Vitamin D3 receptor-interacting protein complex 130 kDa component.
研究領(lǐng)域；細(xì)胞生物 染色質(zhì)和核信號 信號轉(zhuǎn)導(dǎo) 表觀遺傳學(xué)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal dilutions/concentrations
should be determined by the end user.
理論分子量；156kDa
細(xì)胞定位；細(xì)胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human DRIP130/CRSP130: 401-500/1368
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The activation of gene transcription is a
multistep process that is triggered by factors that recognize transcriptional
enhancer sites in DNA. These factors work with co-activators to direct
transcriptional initiation by the RNA polymerase II apparatus. The protein
encoded by this gene is a subunit of the CRSP (cofactor required for SP1
activation) complex, which, along with TFIID, is required for efficient
activation by SP1. This protein is also a component of other multisubunit complexes
e.g. thyroid hormone receptor-(TR-) associated proteins which interact with
TR and facilitate TR function on DNA templates in conjunction with initiation
factors and cofactors. This protein also acts as a metastasis suppressor.
Several alternatively spliced transcript variants encoding different isoforms
have been described for this gene. [provided by RefSeq, Jul 2012] Function: Required for transcriptional activation subsequent
to the assembly of the preinitiation complex. Component of the Mediator
complex, a coactivator involved in the regulated transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey
information from gene-specific regulatory proteins to the basal RNA
polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II and the
general transcription factors. Required for transcriptional activation by
adenovirus E1A protein. Required for ELK1-dependent transcriptional
activation in response to activated Ras signaling. Subunit: Interacts with ELK1 (By similarity). Component of
the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8,
MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18,
MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30,
MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits
form a distinct module termed the CDK8 module. Mediator containing the CDK8
module is less active than Mediator lacking this module in supporting
transcriptional activation. Individual preparations of the Mediator complex
lacking one or more distinct subunits have been variously termed ARC, CRSP,
DRIP, PC2, SMCC and TRAP. Interacts with CEBPB, CTNNB1, and GLI3. Interacts
with the adenovirus E1A protein. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進(jìn)行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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