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簡(jiǎn)要描述：早期生長(zhǎng)反應(yīng)蛋白4抗體免 疫 原；KLH conjugated synthetic peptide derived from human EGR4: 501-589/589
產(chǎn)品型號(hào)：GOY-01K1736廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：144產(chǎn)品分類
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早期生長(zhǎng)反應(yīng)蛋白4抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
早期生長(zhǎng)反應(yīng)蛋白4抗體 | EGR4 | GOY-01K1736 |
商品屬性：
英文名稱: EGR4
中文名:早期生長(zhǎng)反應(yīng)蛋白4抗體
別 名；AT133; EGR4_HUMAN； Early growth response protein 4; Nerve growth factor induced clone
C; NGFI C; NGFIC; PAT133.
研究領(lǐng)域；細(xì)胞生物 神經(jīng)生物學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 鋅指蛋白
抗體來(lái)源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other
applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；62kDa
細(xì)胞定位；細(xì)胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human EGR4: 501-589/589
亞 型；IgG
純化方法；affinity
purified by Protein A
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Egr-1, Egr-2, Egr-3 and Egr-4 are nuclear
transcription factors belonging to the Egr C2H2-type zinc-finger protein
family and containing three C2H2-type zinc fingers. As immediate early
proteins, Egr transcription factors are rapidly induced by diverse
extracellular stimuli. They are subject to tight differential control through
diverse mechanisms at several levels of regulation: transcriptional;
translational and posttranslational (including glycosylation, phosphorylation
and redox) mechanisms; and protein-protein interaction. Egr-1 binds to the
DNA sequence 5'-CGCCCCCGC-3' (Egr-site), thereby activating transcription of
target genes whose products are required for mitogenisis and differentiation.
Egr-2 binds specific DNA sites located in the promoter region of HoxA4. Egr-2
defects cause congenital hypomyelination neuropathy (also designated
Charcot-Marie-Tooth disease) and Dejerine-Sottas neuropathology (also
designated hereditary motor and sensory neuropathy III). Egr-3 is involved in
muscle spindle development and is expressed in T cells 20 minutes following
activation. Egr-4 binds to the Egr consensus motif GCGTGGGCG, functions as a
transcriptional repressor, and displays autoregulatory activities,
downregulating its own gene promoter in a dose dependent manner. Function: EGR4(Early Growth Response protein 4) is a
zinc-finger transcription factor that activates the transcription of genes
whose products are required for mitogenesis and differentiation. EGR4 is
closely related to nerve growth factor-induced clone A (NGFI-A or EGR1), EGR2,
and EGR3. These four early response (immediate early) proteins all contain
very similar zinc-finger DNA binding domains and five highly homologous
subdomains. EGR4 functionally cooperate with NFAT proteins and induce
expression of IL2 and TNFalpha. Early growth response proteins (EGR) and
nuclear factors of activated T cells (NFAT) form heterodimers and regulate
proinflammatory cytokine gene expression. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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