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簡(jiǎn)要描述：eIF4A1蛋白抗體免 疫 原；KLH conjugated synthetic peptide derived from human eIF4A1: 21-120/406
產(chǎn)品型號(hào)：GOY-01K0421廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：131產(chǎn)品分類(lèi)
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eIF4A1蛋白抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
eIF4A1蛋白抗體 | eIF4A1 | GOY-01K0421 |
商品屬性：
英文名稱: eIF4A1
中文名:eIF4A1蛋白抗體
別 名；ATP-dependent RNA
helicase eIF4A-1; DDX2; DDX2A; eIF 4A I; eIF-4A-I; EIF4A; eIF4A I; eIF4A-I;
EIF4A1; Eukaryotic initiation factor 4A-I; Eukaryotic initiation factor 4AI;
eukaryotic translation initiation factor 4A, isoform 1; Eukaryotic translation
initiation factor 4A1; IF4A1_HUMAN.
研究領(lǐng)域；細(xì)胞生物 結(jié)合蛋白 表觀遺傳學(xué)
抗體來(lái)源；Rabbit
克隆類(lèi)型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；46kDa
細(xì)胞定位；細(xì)胞漿 細(xì)胞外基質(zhì) 分泌型蛋白
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human eIF4A1: 21-120/406
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Translation initiation in eukaryotes necessitates
the assembly of an 80S ribosomal complex. Eukaryotic initiation factors
(eIFs) are utilized in a sequence of reactions that leads to 80S ribosomal
assembly and initiation of translation. Mammalian eukaryotic translation
initiation factor 4F (eIF4F) is a protein complex that contains eIF4A, eIF4E
and eIF4G, binds mRNA at a 5’-cap
motif and recruits the 43S ribosomal preinitiation complex to the eligible
transcript. Along with eIF4B, the eIF4F complex mediates the unwinding of
mRNA secondary structure to facilitate ribosome association. eIF4E
specifically interacts with the 5’ cap, eIF4A(I,II)
are bidirectional RNA helicases, and eIF4G(I,II) are scaffolding proteins
which coordinate eIF4E, eIF4A, eIF3 and the 40S ribosome. Human eIF4AI
(eIF4A, DDX2A) is a 406 amino acid protein that is 92.7% homologous to mouse
eIF4AI. The promoter region of human eIF4A1 contains TATA and CAAT motifs and
consensus binding sites to Sp1 and AP2. Function: ATP-dependent RNA helicase which is a subunit of
the eIF4F complex involved in cap recognition and is required for mRNA
binding to ribosome. In the current model of translation initiation, eIF4A
unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to
allow efficient binding of the small ribosomal subunit, and subsequent
scanning for the initiator codon. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類(lèi)型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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