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簡要描述：胞吞調(diào)控蛋白Eps15抗體免 疫 原；KLH conjugated synthetic peptide derived from human EPS15: 161-260/896
產(chǎn)品型號：GOY-01K2274廠商性質：科研更新時間：2023-10-24 00:00:00訪 問 量：136產(chǎn)品分類
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胞吞調(diào)控蛋白Eps15抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
胞吞調(diào)控蛋白Eps15抗體 | EPS15 | GOY-01K2274 |
商品屬性：
英文名稱: EPS15
中文名:胞吞調(diào)控蛋白Eps15抗體
別 名；AF 1P; AF 1p
protein; AF1P; ALL1 fused gene from chromosome 1; Epidermal growth factor
receptor pathway substrate 15; Epidermal growth factor receptor substrate 15;
EPS 15; MLLT 5; MLLT5; Protein Eps 15; Protein Eps15; EPS15_HUMAN.
研究領域；腫瘤 信號轉導 生長因子和激素
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應；(predicted:
Human, Mouse, Rat, Pig, )
產(chǎn)品應用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；99kDa
細胞定位；細胞漿 細胞膜
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human EPS15: 161-260/896
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Elucidation of the mechanism by which receptor
tyrosine kinases (RTKs) modulate cellular physiology in response to stimuli
is critical to the understanding of growth regulation. Miscues in RTK
signaling pathways can result in cellular transformation and ultimately in
cancer. Two novel EGF receptor substrates designated EGF-receptor pathway
substrates 8 and 15, or Eps8 and Eps15, have been described. Eps8 and Eps15
are proteins, respectively that become tyrosine phosphorylated subsequent to
EGF stimulation. Overexpression of Eps15 in NIH/3T3 cells causes cellular
transformation, implying involvement in the regulation of cell proliferation.
Eps15 is capable of binding the amino terminal portion of Crk via a conserved
proline-rich domain, characteristic of all Crk binding proteins (5).
Overexpression of Eps8 in both fibroblasts and hematopoietic cells results in
an increased mitogenic response to EGF. Eps8 has been shown to associate with
the EGF receptor despite its lack of a functional SH2 domain. Further
characterization suggests the protein has both a PH domain and a SH3 domain,
the functional significance of which are not yet known. The eps15 protein (EGFR pathway substrate clone
15) is tyrosine phosphorylated by the activation of the EGF and PDGF
receptors. It was first identified as an 896 amino acid protein in mouse.
Subsequent cloning of the human protein showed 90% homology to the mouse
form. Several physiological functions have been proposed for eps15.
Phosphorylation by EGF and PDGF receptors indicates that eps15 plays a role
in signal transduction, cell proliferation and endocytosis. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結果是陽性。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應用驗證需求。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務，包含鼠源單克隆抗體構建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務，如動物免疫、動物飼養(yǎng)、抗體修飾服務（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務。
抗體定制服務:
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務，主要面向工業(yè)客戶。
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