簡(jiǎn)要描述:ETV3蛋白抗體免 疫 原;KLH conjugated synthetic peptide derived from human ETV3: 65-165/512
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ETV3蛋白抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
ETV3蛋白抗體 | ETV3 | GOY-01K0794 |
商品屬性:
英文名稱: ETV3
中文名:ETV3蛋白抗體
別 名;AI414410;
bA110J1.4; ETS domain transcriptional repressor PE1; ETS family transcriptional
repressor; ETS translocation variant 3; ets variant 3; ets variant gene 3; ets
variant gene 3, ETS family transcriptional repressor; ETV3; ETV3_HUMAN; ME PE1;
METS; Mitogenic Ets transcriptional suppressor; Oncogene PE1; PE 1; PE-1; PE1.
研究領(lǐng)域;細(xì)胞生物 轉(zhuǎn)錄調(diào)節(jié)因子 細(xì)胞分化 表觀遺傳學(xué)
抗體來源;Rabbit
克隆類型;Polyclonal
交叉反應(yīng);(predicted:
Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep, )
產(chǎn)品應(yīng)用;ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;57kDa
細(xì)胞定位;細(xì)胞核
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human ETV3: 65-165/512
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件;Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng);This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
ETV3 belongs to the ETS family of transcription
factors and functions as a transcriptional repressor. ETS family members
share a highly conserved DNA binding domain and play a role in growth factor
pathways regulating proliferation and differentiation. PE-1 is ubiquitously
expressed and localizes to the nucleus. Its expression can be induced by
IL-10 via the STAT3 pathway suggesting that PE-1 contributes to the IL-10
downstream anti-inflammatory effects. During terminal cell differentiation,
PE-1 plays a role in growth arrest by specifically repressing the target
genes that are involved in Ras-dependent proliferation. The contributions of
PE-1 to these anti-proliferative effects are heavily dependent on its
interaction with Gemin3. Two PE-1 isoforms exist due to alternative splicing
events. Function: Transcriptional repressor that contribute to
growth arrest during terminal macrophage differentiation by repressing target
genes involved in Ras-dependent proliferation. Represses MMP1 promoter
activity. |
多克隆抗體制備:
我公司合成抗原,保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1:32000,由蛋白抗原制備的多抗,保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行,我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中,與客戶互動(dòng)驗(yàn)證,確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí),也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái),能為客戶提供各種類型的重組抗體表達(dá)服務(wù),包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá),抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù),如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)(如FITC,HRP等的標(biāo)記)、以及ELISA,WB,IHC,DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo),主要用于抗體藥物發(fā)現(xiàn)和開發(fā),是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù),主要面向工業(yè)客戶。
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