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簡要描述：EYA3蛋白抗體免 疫 原；KLH conjugated synthetic peptide derived from human EYA3: 371-470/573
產(chǎn)品型號(hào)：GOY-01K1127廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問 量：146產(chǎn)品分類
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EYA3蛋白抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
EYA3蛋白抗體 | EYA3 | GOY-01K1127 |
商品屬性：
英文名稱: EYA3
中文名:EYA3蛋白抗體
別 名；AI844637;
DKFZp686C132; EYA3; EYA3_HUMAN; Eyes absent 3; Eyes absent 3 homolog
(Drosophila); Eyes absent homolog 3; OTTMUSP00000010370; RP11-460I13.4;
RP23-442A20.1.
研究領(lǐng)域；細(xì)胞生物 發(fā)育生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 干細(xì)胞 轉(zhuǎn)錄調(diào)節(jié)因子 激酶和磷酸酶 表觀遺傳學(xué)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；63kDa
細(xì)胞定位；細(xì)胞核 細(xì)胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH conjugated
synthetic peptide derived from human EYA3: 371-470/573
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
EYA3 is a 573 amino acid protein that localizes to
both the nucleus and the cytoplasm and is one of several mammalian homologs
of the Drosophila Eya (eyes absent) protein. Existing as two alternatively
spliced isoforms, EYA3 possesses magnesium-catalyzed phosphatase activity and
is thought to play a role in transcriptional regulation during organogenesis.
Specifically, EYA3 interacts with proteins such as Six1 and, via this
interaction, functions to activate the expression of genes that are involved
in cellular proliferation and organ development. Upon DNA damage, EYA3 may be
phosphorylated by ATM or ATR. The gene encoding EYA3 maps to chromosome 1,
which spans about 260 million base pairs and comprises nearly 8% of the human
genome. Function: Tyrosine phosphatase that specifically
dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142'
phosphorylation of histone H2AX plays a central role in DNA repair and acts
as a mark that distinguishes between apoptotic and repair responses to
genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX,
promoting the recruitment of DNA repair complexes containing MDC1. Its
function as histone phosphatase probably explains its role in transcription
regulation during organogenesis. Coactivates SIX1, and seems to coactivate
SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in
myoblasts by SIX1 is switched to activation through recruitment of EYA3 to
the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity
(By similarity). May be involved in development of the eye. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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