簡要描述:P38相互作用蛋白抗體免 疫 原;KLH conjugated synthetic peptide derived from human FAM48A: 21-120/779
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P38相互作用蛋白抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
P38相互作用蛋白抗體 | FAM48A | GOY-01K1280 |
商品屬性:
英文名稱: FAM48A
中文名:P38相互作用蛋白抗體
別 名;SP20H_HUMAN;
Transcription factor SPT20 homolog; p38-interacting protein; p38IP.
研究領(lǐng)域;腫瘤 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 激酶和磷酸酶
抗體來源;Rabbit
克隆類型;Polyclonal
交叉反應(yīng);(predicted:
Human, Mouse, Rat, Cow, )
產(chǎn)品應(yīng)用;ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;86kDa
細(xì)胞定位;細(xì)胞核
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human FAM48A: 21-120/779
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項;This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
FAM48A is a 779 amino acid protein that interacts
with p38 MAP kinase. Specifically, FAM48A and p38 are required for
downregulation of E-cadherin during gastrulation. In adult tissues, FAM48A is
highly expressed in testis and moderately expressed in brain and pituitary
gland. It is also expressed in several fetal tissues, including lung, brain,
thymus and kidney. Expression of FAM48A has been shown to be downregulated in
malignant prostate tissues. The gene encoding FAM48A maps to human chromosome
13, which houses over 400 genes and comprises approximately 4% of the human
genome. Key tumor suppressor genes on chromosome 13 include the breast cancer
susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene. Required for MAP kinase p38 (MAPK11, MAPK12,
MAPK13 and/or MAPK14) activation during gastrulation. Required for
down-regulation of E-cadherin during gastrulation by regulating E-cadherin
protein level downstream from NCK-interacting kinase (NIK) and independently
of the regulation of transcription by Fgf signaling and Snail (By
similarity). Required for starvation-induced ATG9A trafficking during
autophagy. |
多克隆抗體制備:
我公司合成抗原,保證陽性血清和抗體ELISA效價達(dá)到1:32000,由蛋白抗原制備的多抗,保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價,按節(jié)點收費(fèi),為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進(jìn)行,我公司將為您的項目提供專業(yè)的建議。在制備過程中,與客戶互動驗證,確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時,也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價,按節(jié)點收費(fèi),為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺,能為客戶提供各種類型的重組抗體表達(dá)服務(wù),包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá),抗體人源化改造及表達(dá)等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù),如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)(如FITC,HRP等的標(biāo)記)、以及ELISA,WB,IHC,DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo),主要用于抗體藥物發(fā)現(xiàn)和開發(fā),是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù),主要面向工業(yè)客戶。
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