簡(jiǎn)要描述:甲精結(jié)合蛋白17抗體免 疫 原;KLH conjugated synthetic peptide derived from human FBP17: 331-430/617
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甲精結(jié)合蛋白17抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
甲精結(jié)合蛋白17抗體 | FBP17 | GOY-01K0701 |
商品屬性:
英文名稱: FBP17
中文名:甲精結(jié)合蛋白17抗體
別 名;FBP1; FBP17;
FNBP1; FNBP1_HUMAN; Formin binding protein 1; Formin binding protein 17; Formin-binding
protein 1; Formin-binding protein 17; hFBP17; KIAA0554; MGC126804.
研究領(lǐng)域;細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 結(jié)合蛋白 上皮細(xì)胞
抗體來(lái)源;Rabbit
克隆類型;Polyclonal
交叉反應(yīng);(predicted:
Human, Mouse, Rat, Dog, Cow, Horse, Zebrafish, Sheep, )
產(chǎn)品應(yīng)用;ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;71kDa
細(xì)胞定位;細(xì)胞漿 細(xì)胞膜
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human FBP17: 331-430/617
亞 型;IgG
純化方法;affinity purified
by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng);This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
FNBP1 is a 617 amino acid protein that localizes
to a variety of locations within the cell, including the cytoplasm,
cytoskeleton, lysosome and the cell cortex, and contains one FCH domain, one
REM repeat and one SH3 domain. Expressed at high levels in respiratory,
reproductive and urinary systems, as well as in brown adipose tissue and
epithelial cells of the gastrointestinal tract, FNBP1 interacts with Rho 7
and links the Actin cytoskeleton with Rho 7 signaling, playing a crucial role
in membrane tubulation and cytoskeletal reorganization during endocytosis.
Additionally, FNBP1, which exists as four alternatively spliced isoforms,
enhances Actin polymerization and promotes membrane invagination and the
formation of tubules. Chromosomal aberrations in the FNBP1 gene are
associated with acute leukemias, suggesting a role for defective FNBP1 in
carcinogenesis. May act as a link between RND2 signaling and
regulation of the actin cytoskeleton (By similarity). Required to coordinate
membrane tubulation with reorganization of the actin cytoskeleton during
endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate
and phosphatidylserine and promotes membrane invagination and the formation
of tubules. Also enhances actin polymerization via the recruitment of
WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization
may promote the fission of membrane tubules to form endocytic vesicles. May
be required for the lysosomal retention of FASLG/FASL. |
多克隆抗體制備:
我公司合成抗原,保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1:32000,由蛋白抗原制備的多抗,保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行,我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中,與客戶互動(dòng)驗(yàn)證,確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí),也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái),能為客戶提供各種類型的重組抗體表達(dá)服務(wù),包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá),抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù),如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)(如FITC,HRP等的標(biāo)記)、以及ELISA,WB,IHC,DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo),主要用于抗體藥物發(fā)現(xiàn)和開發(fā),是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù),主要面向工業(yè)客戶。
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