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簡要描述：FBXW12蛋白抗體免 疫 原；KLH conjugated synthetic peptide derived from human FBXW12/FBXO35: 101-200/464
產(chǎn)品型號：GOY-01K4179廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：136產(chǎn)品分類
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FBXW12蛋白抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
FBXW12蛋白抗體 | FBXW12 | GOY-01K4179 |
商品屬性：
英文名稱: FBXW12
中文名:FBXW12蛋白抗體
別 名；F box and WD 40
domain containing protein 12; F box and WD 40 domain protein 12; F box and WD
repeat domain containing 12; F box and WD40 repeat containing protein; F box
only protein 35; F box/WD repeat containing protein 12; F-box and WD-40
domain-containing protein 12; F-box only protein 35; F-box/WD repeat-containing
protein 12; Fbw12; FBW12_HUMAN; FBX12; FBXO12; FBXO35; FBXW 12; FBXW12.
研究領(lǐng)域；細(xì)胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞周期蛋白
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；53kDa
細(xì)胞定位；細(xì)胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human FBXW12/FBXO35: 101-200/464
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Belonging to the F-box family of proteins, FBXO35
(F-box only protein 35), also designated F-box and WD-40 domain-containing
protein 12 (FBXW12 or FBXO12), is a 464 amino acid protein that contains one
C-terminal F-box domain. F-box proteins are critical components of the SCF
(Skp1-CUL-1-F-box protein)-type E3 ubiquitin ligase complex and are involved
in substrate recognition and recruitment for ubiquitination. They are members
of a larger family of proteins that are involved in the regulation of a wide
variety of cellular mechanisms, including the cell cycle, the immune
response, signaling cascades and developmental processes. They function by
targeting proteins, such as cyclins, cyclin-dependent kinase inhibitors, I?B-? and ∫-catenin, for
degradation by the proteasome after ubiquitination. Via its F-box domain,
FBXO35 can directly interact with Skp1 p19 and CUL-1. FBXO35 is ubiquitously
expressed at low levels in most human tissues. Function: Substrate-recognition component of the SCF
(SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity). |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報價，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中，與客戶互動驗(yàn)證，確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報價，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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