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簡要描述：“衰老關(guān)鍵蛋白”抗體免 疫 原；KLH conjugated synthetic peptide derived from human Fibulin 1: 501-600/703
產(chǎn)品型號：GOY-01K0092廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：135產(chǎn)品分類
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“衰老關(guān)鍵蛋白”抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
“衰老關(guān)鍵蛋白”抗體 | Fibulin 1 | GOY-01K0092 |
商品屬性：
英文名稱: Fibulin 1
中文名:“衰老關(guān)鍵蛋白”抗體
別 名；Basement membrane
protein 90; BM 90; FBLN; FBLN1; FIBL 1; FIBL1; Fibulin 1; FBLN1_HUMAN; FIBL-1;
Fibulin-1.
研究領(lǐng)域；腫瘤 心血管 細胞生物 免疫學(xué) 內(nèi)分泌病
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；74kDa
細胞定位；細胞外基質(zhì) 分泌型蛋白
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human Fibulin 1: 501-600/703
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Fibulin-1 is an extracellular matrix protein often
associated with fibronectin (FN) in vivo. Fibulin-1 was found to have
pronounced inhibitory effects on the cell attachment and spreading promoted
by FN. Fibulin-1 was also found to inhibit the motility of a variety of cell
types on FN substrata. For example, the FN-dependent haptotactic motility of
breast carcinoma (MDA MB231) cells, epidermal carcinoma (A431), melanoma
(A375 SM), rat pulmonary aortic smooth muscle cells (PAC1) and Chinese
hamster ovary (CHO) cells was inhibited by the presence of fibulin-1 bound to
FN-coated Boyden chamber membranes. Cells transfected to overproduce
fibulin-1 displayed reduced velocity, distance of movement and persistence
time on FN substrata. Similarly, the incorporation of fibulin-1 into
FN-containing type I collagen gels inhibited the invasion of endocardial
cushion mesenchymal cells migrating from cultured embryonic heart explants.
By contrast, incorporation of fibulin-1 into collagen gels lacking FN had no
effect on the migration of endocardial cushion cells. Function: Incorporated into fibronectin-containing matrix
fibers. May play a role in cell adhesion and migration along protein fibers
within the extracellular matrix (ECM). Could be important for certain
developmental processes and contribute to the supramolecular organization of
ECM architecture, in particular to those of basement membranes. Has been
implicated in a role in cellular transformation and tumor invasion, it
appears to be a tumor suppressor. May play a role in haemostasis and
thrombosis owing to its ability to bind fibrinogen and incorporate into
clots. Could play a significant role in modulating the neurotrophic
activities of APP, particularly soluble APP. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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