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簡要描述：高嗜酸性粒細(xì)胞綜合癥相關(guān)蛋白FIP1L1抗體免 疫 原；KLH conjugated synthetic peptide derived from human FIP1L1: 501-594/594
產(chǎn)品型號(hào)：GOY-01K1198廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問 量：125產(chǎn)品分類
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高嗜酸性粒細(xì)胞綜合癥相關(guān)蛋白FIP1L1抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
高嗜酸性粒細(xì)胞綜合癥相關(guān)蛋白FIP1L1抗體 | FIP1L1 | GOY-01K1198 |
商品屬性：
英文名稱: FIP1L1
中文名:高嗜酸性粒細(xì)胞綜合癥相關(guān)蛋白FIP1L1抗體
別 名；DKFZp586K0717;
Factor interacting with PAP; FIP1; FIP1 like 1 (S cerevisiae); FIP1 like 1;
FLJ33619; hFip 1; hFip1; Pre mRNA 3 end processing factor FIP1; Rearranged in
hypereosinophilia; RHE; FIP1_HUMAN.
研究領(lǐng)域；細(xì)胞生物 表觀遺傳學(xué)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；66kDa
細(xì)胞定位；細(xì)胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human FIP1L1: 501-594/594
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The Component of the Cleavage and Polyadenylation
Specificity Factor (CPSF) complex plays an important role in the 3'-end
formation of pre-mRNA. This complex recognizes the AAUAAA signal sequence and
interacts with poly(A) polymerase to process and add to the poly(A) tail.
FIP1L1 (FIP1-like 1), also known as Pre-mRNA 3'-end-processing factor FIP1,
FIP1 (Factor interacting with PAP) and RHE (Rearranged in hypereosinophilia),
is a 594 amino acid nuclear protein that is a component of the CPSF complex.
Within the complex, FIP1L1 contributes to the poly(A) recognition and
stimulates poly(A) addition. Fusion of the genes encoding FIP1L1 and PDGFRA
due to an interstitial deletion on chromosome 4q12 is the cause of
hypereosinophilia syndrome, a rare blood disorder characterized by continuous
overproduction of eosinophils in the bone marrow that leads to tissue
infiltration and organ damage. There are three isoforms of FIP1L1 that are
produced as a result of alternative splicing events. FIP1L1 is an integral subunit of the cleavage and
polyadenylation specificity factor (CPSF) complex. CPSF is a multisubunit
complex that binds to the canonical AAUAAA hexamer and to U-rich upstream
sequence elements on the pre-mRNA and interacts with poly(A) polymerase and
other factors to bring about cleavage and poly(A) addition. FIP1L1 binds to
U-rich RNA sequence elements surrounding the poly(A) site and contributes to
poly(A) site recognition and stimulates poly(A) addition. FIP1L1 may act to
tether poly(A) polymerase to the CPSF complex. A fusion of FIP1L1 and PDGFRA
(FIP1L1-PDGFRA) is a recurrent molecular lesion in eosinophilia-associated
myeloproliferative disorders. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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