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簡要描述：脆性X綜合征相關(guān)蛋白AFF1抗體免 疫 原；KLH conjugated synthetic peptide derived from human FMRP: 112-210/632
產(chǎn)品型號：GOY-01K2153廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：129產(chǎn)品分類
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脆性X綜合征相關(guān)蛋白AFF1抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
脆性X綜合征相關(guān)蛋白AFF1抗體 | FMR1 | GOY-01K2153 |
商品屬性：
英文名稱: FMR1
中文名:脆性X綜合征相關(guān)蛋白AFF1抗體
別 名；FMR 1; FMR1;
FMR1_HUMAN; FMRP; FMRP1; Fragile X mental retardation 1; Fragile X mental
retardation 1 protein; FRAXA; POF; POF1; Protein FMR-1; Protein FMR1.
研究領(lǐng)域；細胞生物 神經(jīng)生物學(xué) 表觀遺傳學(xué)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；70kDa
細胞定位；細胞核 細胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human FMRP: 112-210/632
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
?Fragile X syndrome is the most frequent form of
inherited mental retardation and is the result of transcriptional silencing
of the FMR1 gene on the X chromosome. The FMR1 gene contains a distinct CpG
dinucleotide repeat located in the 5' untranslated region of the gene. In
fragile X syndrome this tandem repeat is substantially amplified and
subjected to extensive methylation and enhanced transcriptional silencing.
The FMR1 protein (or FMRP) is an RNA-binding protein that associates with
polyribosomes and is a likely component of a messenger ribonuclear protein
(mRNP) particle. It contains several features that are characteristics of
RNA-binding proteins, including two hnRNPK homology (KH) domains and an RGG
amino acid motif (RGG box). FMR1 localizes to both the nucleus and the
cytoplasm and can also interact with two fragile X syndrome related factors,
FXR1 and FXR2, which form heterodimers through their N-terminal coiled-coil
domains. Since FMR1 contains both a nuclear localization signal and a nuclear
export signal it is also implicated in the nucleocytoplasmic transport of
mRNAs. Translation repressor. Component of the
CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates
translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit
mediates translation repression (By similarity). RNA-binding protein that
plays a role in intracellular RNA transport and in the regulation of
translation of target mRNAs. Associated with polysomes. May play a role in
the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to
poly(G), binds moderately to poly(U) but shows very little binding to poly(A)
or poly(C). |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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