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簡要描述：GATA結(jié)合蛋白2伴侶蛋白抗體免 疫 原；KLH conjugated synthetic peptide derived from human FOG2: 701-800/1151
產(chǎn)品型號：GOY-01K0256廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：152產(chǎn)品分類
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GATA結(jié)合蛋白2伴侶蛋白抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
GATA結(jié)合蛋白2伴侶蛋白抗體 | FOG2 | GOY-01K0256 |
商品屬性：
英文名稱: FOG2
中文名:GATA結(jié)合蛋白2伴侶蛋白抗體
別 名；FOG-2;
FOG2_HUMAN; Friend of GATA 2; Friend of GATA protein 2; Friend of GATA2 ;
hFOG-2 ; ZFPM2; Zinc finger protein 89B; Zinc finger protein M2; Zinc finger
protein multitype 2 ; Zinc finger protein ZFPM2.
研究領(lǐng)域；心血管 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 鋅指蛋白 表觀遺傳學(xué)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；128kDa
細(xì)胞定位；細(xì)胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human FOG2: 701-800/1151
亞 型；IgG
純化方法；affinity purified
by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The FOG family of transcriptional cofactors,
including FOG (friend of GATA-1) and FOG-2, are zinc finger proteins that
interact with the GATA family of transcriptional regulators. FOG/GATA-1
complexes are required for erythroid and megakaryocyte maturation, and they
promote differentiation during embryonic development. These complexes involve
the association between multiple zinc fingers on the FOG proteins and the
N-terminal zinc finger of GATA proteins. While FOG cooperatively regulates
GATA-1 induced transcription, FOG-2 is able to both positively and negatively
influence GATA mediated transcription. FOG-2 is predominantly expressed in
heart, neurons and gonads, and it preferentially participates in the
regulation of GATA-3, GATA-4 and GATA-6. In cardiomyocytes and fibroblasts,
FOG-2 inhibits GATA-4 transcriptional activity, yet FOG-2 restores GATA-1
mediated transcription in erythroid cultures deficient in FOG, suggesting
that the observed effects of FOG-2 are context specific and vary between
cellular systems. Function: Transcription regulator that plays a central role
in heart morphogenesis and development of coronary vessels from epicardium,
by regulating genes that are essential during cardiogenesis. Essential
cofactor that acts via the formation of a heterodimer with transcription
factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both
activate or repress transcriptional activity, depending on the cell and
promoter context. Also required in gonadal differentiation, possibly be
regulating expression of SRY. Probably acts a corepressor of NR2F2. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進(jìn)行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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