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簡要描述：調(diào)節(jié)蛋白GAL4抗體免 疫 原；KLH conjugated synthetic peptide derived from Saccharomyces cerevisiae GAL4: 21-120/881
產(chǎn)品型號：GOY-01K4646廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：177產(chǎn)品分類
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調(diào)節(jié)蛋白GAL4抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
調(diào)節(jié)蛋白GAL4抗體 | GAL4 | GOY-01K4646 |
商品屬性：
英文名稱: GAL4
中文名:調(diào)節(jié)蛋白GAL4抗體
別 名；Gal4p; GAL81;
Homo sapiens galectin4 mRNA complete cds; Regulatory protein GAL4; GAL4_YEAST.
研究領域；腫瘤 細胞生物 信號轉導 轉錄調(diào)節(jié)因子 表觀遺傳學
抗體來源；Rabbit
克隆類型；Polyclonal
產(chǎn)品應用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；99kDa
細胞定位；細胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from Saccharomyces cerevisiae GAL4:
21-120/881
亞 型；IgG
純化方法；affinity purified
by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The GAL4 protein of Saccharomyces cerevisiae is
one of the most thoroughly characterized transcriptional activators. As the
N-terminal 147 amino acid residues of GAL4 are sufficient to mediate specific
and strong binding to DNA, but are incapable of efficient transcriptional
activation, this protein fragment has frequently been used to confer specific
DNA binding in experiments examining transcriptional activation functions of
heterologous proteins. This approach is facilitated by the finding that
higher eukaryotes lack endogenous proteins that enhance transcription from
the consensus GAL4-binding site. Fusions between GAL4 (amino acids 1-147) and
activating domains from a variety of transcriptional regulatory proteins can
activate transcription in yeast, plant, insects and mammalian cells. Fields
and coworkers have taken advantage of these findings by the development of a
unique “two-hybrid” system using GAL4 fusions in yeast to identify specific
protein-protein interactions. This protein is a positive regulator for the gene
expression of the galactose-induced genes such as GAL1, GAL2, GAL7, GAL10,
and MEL1 which encode for the enzymes used to convert galactose to glucose.
It recognizes a 17 base pair sequence in (5'-CGGRNNRCYNYNCNCCG-3') the
upstream activating sequence (UAS-G) of these genes. Subunit structure: Binds
DNA as a homodimer. Interacts directly with the mediator subunits GAL11/MED15
and SRB4/MED17. Domain: The 9aaTAD motif (residues 862 to 870) is a
transactivation domain present in a large number of yeast and animal transcription
factors. Post-translational modification: Association between GAL11 and GAL4
may serve to expedite phosphorylation of GAL4. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結果是陽性。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應用驗證需求。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務，包含鼠源單克隆抗體構建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務，如動物免疫、動物飼養(yǎng)、抗體修飾服務（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務。
抗體定制服務:
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務，主要面向工業(yè)客戶。
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