簡(jiǎn)要描述:鳥(niǎo)苷酸環(huán)化酶激活蛋白2抗體免 疫 原;KLH conjugated synthetic peptide derived from human GCAP2: 21-120/200
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鳥(niǎo)苷酸環(huán)化酶激活蛋白2抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
鳥(niǎo)苷酸環(huán)化酶激活蛋白2抗體 | GCAP2 | GOY-01K1232 |
商品屬性:
英文名稱: GCAP2
中文名:鳥(niǎo)苷酸環(huán)化酶激活蛋白2抗體
別 名;GCAP 2; Guanylate
Cyclase Activating Protein Photoreceptor 2; Guanylate Cyclase Activator 1B;
Guanylin 2; Guanylyl cyclase-activating protein 2; GUC1B_HUMAN; GUCA 2; GUCA1B.
研究領(lǐng)域;細(xì)胞生物 神經(jīng)生物學(xué) 結(jié)合蛋白 G蛋白偶聯(lián)受體 G蛋白信號(hào)
抗體來(lái)源;Rabbit
克隆類型;Polyclonal
交叉反應(yīng);(predicted:
Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用;WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;23kDa
細(xì)胞定位;細(xì)胞膜
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human GCAP2: 21-120/200
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng);This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The intracellular stimulation of guanylate cyclase
(GC) by calcium, a key event in the recovery of the dark state of rod
photoreceptors after exposure to light, is mediated by guanylate
cyclase-activating protein (GCAP1). GCAPs are calcium-binding proteins
belonging to the calmodulin superfamily. GCAP1 is a calcium-binding protein
that stimulates synthesis of cGMP in photoreceptors. GCAP1 is present in rod
and cone photoreceptor outer segments where phototransduction occurs. In
contrast to other calcium-binding proteins from the calmodulin superfamily,
the calcium-free form of GCAP1 stimulates the effector enzyme. By molecular
cloning of human and mouse GCAP cDNA, the known mammalian GCAPs are found to
be more than 90% similar, consisting of 201 to 205 amino acids and containing
three identically conserved calcium-binding sites. A related protein, GCAP2,
is detectable only in the retina and results from a gene duplication event.
The genes which encode GCAP1 and GCAP2 map to human chromosome 6p21.1. Stimulates guanylyl cyclase 1 (GC1) and GC2 when
free calcium ions concentration is low, and GC1 and GC2 when free calcium
ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a
key event in recovery of the dark state of rod photoreceptors following light
exposure. |
多克隆抗體制備:
我公司合成抗原,保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1:32000,由蛋白抗原制備的多抗,保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行,我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中,與客戶互動(dòng)驗(yàn)證,確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí),也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái),能為客戶提供各種類型的重組抗體表達(dá)服務(wù),包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá),抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù),如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)(如FITC,HRP等的標(biāo)記)、以及ELISA,WB,IHC,DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo),主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā),是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù),主要面向工業(yè)客戶。
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