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簡(jiǎn)要描述：Gemin8蛋白抗體免 疫 原；KLH conjugated synthetic peptide derived from human Gemin 8: 1-100/242
產(chǎn)品型號(hào)：GOY-01K2528廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：148產(chǎn)品分類
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Gemin8蛋白抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
Gemin8蛋白抗體 | Gemin 8 | GOY-01K2528 |
商品屬性：
英文名稱: Gemin 8
中文名:Gemin8蛋白抗體
別 名；Gemin-8; FAM51A1;
FLJ20514; FLJ43072; gem (nuclear organelle) associated protein 8.
研究領(lǐng)域；細(xì)胞生物 表觀遺傳學(xué)
抗體來(lái)源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；29kDa
細(xì)胞定位；細(xì)胞漿 細(xì)胞膜
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human Gemin 8: 1-100/242
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Gemin8 is a 242 amino acid protein encoded by the
mouse gene Gemin8. Gemin8, along with Gemins 2-7 and unrip, is a major
component of the large multiprotein survival of motor neurons (SMN) complex.
The survival of motor neurons (SMN) protein, a product of the disease gene of
the common neurodegenerative disease spinal muscular atrophy, is also part of
the SMN complex. The SMN complex is a modular composition of proteins with
SMN, Gemin8, and Gemin7 in its center. The SMN complex functions as an assembly
machine for small nuclear ribonucleoproteins (snRNPs)-the major components of
the spliceosome. Gemin8 binds directly to SMN and mediates its interaction
with the Gemin6/Gemin7 heterodimer. Importantly, the loss of Gemin6, Gemin7,
and Unrip interaction with SMN as a result of Gemin8 knockdown affects snRNP
assembly by impairing the SMN complex association with Sm proteins but not
with snRNAs. The Gemin6/Gemin7 complex binds to Sm proteins and might help
organize Sm proteins for formation of Sm rings on snRNA targets. Function: Gemin 8 forms a large macromolecular complex which
includes other gemin proteins, SMN (survival motor neuron) protein and Unrip.
This complex is required for assembly of small nuclear ribonucleoproteins
(snRNPs) from Sm proteins and snRNAs. Gemin 8 mediates the binding of SMN
with gemin 6 and gemin 7. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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