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簡要描述：γ-銜接蛋白相關(guān)蛋白1抗體免 疫 原；KLH conjugated synthetic peptide derived from human GGA1: 51-150/639
產(chǎn)品型號(hào)：GOY-01K0682廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問 量：149產(chǎn)品分類
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γ-銜接蛋白相關(guān)蛋白1抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
γ-銜接蛋白相關(guān)蛋白1抗體 | GGA1 | GOY-01K0682 |
商品屬性：
英文名稱: GGA1
中文名:γ-銜接蛋白相關(guān)蛋白1抗體
別 名；4930406E12Rik;
ADP ribosylation factor binding protein 1; ADP ribosylation factor binding
protein GGA1; ADP-ribosylation factor-binding protein GGA1; ARF binding protein
1; ARF-binding protein 1; Gamma adaptin related protein 1; gamma
ear-containing; Gamma-adaptin-related protein 1; GGA 1; GGA1; GGA1 protein;
GGA1_HUMAN; Golgi associated gamma adaptin ear containing ARF; Golgi associated
gamma adaptin ear containing ARF binding protein 1; Golgi localized gamma ear
containing ARF binding protein 1; Golgi-localized; OTTHUMP00000028975;
OTTHUMP00000042200.
研究領(lǐng)域；細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)運(yùn)蛋白
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Sheep, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；70kDa
細(xì)胞定位；細(xì)胞漿 細(xì)胞膜
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human GGA1: 51-150/639
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The GGA family of proteins (Golgi-localized,
ARF-binding proteins) are ubiquitous coat proteins that facilitate the
trafficking of soluble proteins from the trans-Golgi network (TGN) to
endosomes/lysosomes by means of interactions with TGN-sorting receptors, ARF
(ADP-ribosylation factor), and clathrin (1?). Members of the GGA family,
GGA1,GGA2 (also known as VEAR) and GGA3, are multidomain proteins that bind
mannose 6-phosphate receptors (MPRs) (1,2,4). GGAs have modular structures
with an N-terminal VHS (VPS-27, Hrs, and STAM) domain followed by a GAT (GGA
and TOM1) domain, a connecting hinge segment, and a C-terminal GAE (?adaptin
ear) domain (5). The amino-terminal VHS domains of GGAs form complexes with
the cytoplasmic domains of sorting receptors by recognizing acidic-cluster
di-leucine (ACLL) sequences (3). GGA1 and GGA2 do not associate with each
other, but they do colocalize on perinuclear membranes (2). The cytosolic
domain of memapsin 2, but not that of memapsin 1, binds the VHS domains of GGA1
and GGA2 (6). The human GGA1 gene maps to chromosome 22 and encodes a protein
that shares 45% sequence identity with GGA2 and GGA3 (1). Plays a role in protein sorting and trafficking
between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent
recruitment of clathrin to the TGN and binds ubiquitinated proteins and
membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL)
motif. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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