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簡要描述：γ-銜接蛋白相關(guān)蛋白3抗體免 疫 原；KLH conjugated synthetic peptide derived from human GGA3: 51-150/723
產(chǎn)品型號：GOY-01K4509廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：170產(chǎn)品分類
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γ-銜接蛋白相關(guān)蛋白3抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
γ-銜接蛋白相關(guān)蛋白3抗體 | GGA3 | GOY-01K4509 |
商品屬性：
英文名稱: GGA3
中文名:γ-銜接蛋白相關(guān)蛋白3抗體
別 名；ADP ribosylation factor
binding protein 3; ADP ribosylation factor binding protein GGA 3; ADP
ribosylation factor binding protein GGA3; ADP-ribosylation factor-binding
protein GGA3; ARF binding protein GGA 3; ARF binding protein GGA3; ARF-binding
protein 3; gamma ear-containing; GGA 3; GGA3; GGA3_HUMAN; Golgi associated
gamma adaptin ear containing ARF binding protein 3; Golgi localized gamma ear
containing ARF binding protein 3; Golgi-localized; KIAA0154.
研究領(lǐng)域；細(xì)胞生物 轉(zhuǎn)運蛋白
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；78kDa
細(xì)胞定位；細(xì)胞漿 細(xì)胞膜
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human GGA3: 51-150/723
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The GGA family of proteins (Golgi-localized,
g-Adaptin ear-containing, ARF-binding proteins) are ubiquitous coat proteins that
facilitate the trafficking of soluble proteins from the trans-Golgi network
(TGN) to endosomes/lysosomes by means of interactions with TGN-sorting
receptors, ARF (ADP-ribosylation factor), and clathrin. Members of the GGA
family, GGA1,GGA2 (also known as VEAR) and GGA3, are multi-domain proteins
that bind mannose 6-phosphate receptors (MPRs). GGAs have modular structures
with an N-terminal VHS (VPS27, Hrs and STAM) domain followed by a GAT (GGA
and Tom1) domain, a connecting hinge segment and a C-terminal GAE (g-Adaptin
ear) domain. The amino-terminal VHS domains of GGAs form complexes with the
cytoplasmic domains of sorting receptors by recognizing acidic-cluster
di-leucine (ACLL) sequences. The human GGA3 gene maps to chromosome 17 and
encodes a 723 amino acid protein that shares 46% sequence identity with GGA1
and 38% with GGA2. Plays a role in protein sorting and trafficking
between the trans-Golgi network (TGN) and endosomes. Mediates the
ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated
proteins and membrane cargo molecules with a cytosolic acidic
cluster-dileucine (AC-LL) motif. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進(jìn)行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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