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簡(jiǎn)要描述：麥角蛋白抗體免 疫 原；KLH conjugated synthetic peptide derived from wheat Gliadin: 231-296/296
產(chǎn)品型號(hào)：GOY-01K0608廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：136產(chǎn)品分類(lèi)
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麥角蛋白抗體
產(chǎn)品名稱(chēng) | 英文名稱(chēng) | 貨號(hào) |
麥角蛋白抗體 | Gliadin | GOY-01K0608 |
商品屬性：
英文名稱(chēng): Gliadin
中文名:麥角蛋白抗體
別 名；Celiac disease;
gliadin - wheat. 麥醇溶蛋白;
產(chǎn)品類(lèi)型植物抗體
研究領(lǐng)域；糖蛋白
抗體來(lái)源；Rabbit
克隆類(lèi)型；Polyclonal
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；34kDa
細(xì)胞定位；細(xì)胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from wheat Gliadin: 231-296/296
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Gliadin is a glycoprotein that, along with
glutenin, plays a role in the formation of gluten, an ergastic amorphous
mixture of proteins found in wheat, rye, and barley. Gluten is responsible
for the elasticity of kneaded dough, which allows it to be leavened. Gliadin
is approximately 60% soluble in ethanol and contains only intramolecule
disulfide links. Gliadin is also found in a variety of foods as well as in
beer, along with the glycoprotein Hordein. Induction of zonulin release in
intestinal epithelial cells is triggered by Gliadin. This causes an
activation of the zonulin pathway by PKC mediated cytoskeleton reorganization
and tight junction opening leads to a rapid increase in intestinal
permeability to macromolecules. Individuals with disorders such as celiac
disease or Crohn's disease are sensitive to Gliadin since they lack the
enzyme necessary for its digestion and can not tolerate it in their diet. Celiac disease is associated with a CD4+ T-cell
response to epitopes of gliadin presented by HLA-DQ2 or -DQ8 class II MHC
molecules. These epitopes are present in a 33-mer peptide of wheat
alpha-gliadin, residues 56-88, which is resistant to digestion and forms a
substrate for tissue transglutaminase (TG2), generating the glutamic acid residues
essential for binding to HLA-DQ2. The alcohol soluble proteins (prolamins)
from wheat, rye, barley and oats produce the harmful effect of coeliac
disease or gluten sensitive enteropathy in humans by causing characteristic
changes in the intestinal mucosa. Patients so affected must avoid eating
these grains and replace them with rice, corn, potatoes, etc. Many
gluten-free foods are produced industrially, thus several immunoassays have
been developed for determination of gliadin in supposedly gluten-free foods. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶(hù)節(jié)約成本。
鼠單克隆抗體制備:
客戶(hù)可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專(zhuān)業(yè)的建議。在制備過(guò)程中，與客戶(hù)互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿(mǎn)足客戶(hù)抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶(hù)節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶(hù)提供各種類(lèi)型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶(hù)提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶(hù)量身定制的專(zhuān)業(yè)服務(wù)，主要面向工業(yè)客戶(hù)。
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