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簡要描述：結(jié)合球蛋白β抗體免 疫 原；KLH conjugated synthetic peptide derived from human Haptoglobulin beta: 311-406/406
產(chǎn)品型號：GOY-01K0544廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：137產(chǎn)品分類
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結(jié)合球蛋白β抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
結(jié)合球蛋白β抗體 | Haptoglobin beta | GOY-01K0544 |
商品屬性：
英文名稱: Haptoglobin beta
中文名:結(jié)合球蛋白β抗體
別 名；Binding peptide;
BP antibody Haptoglobin alpha(1S) beta; Haptoglobin alpha(2FS) beta;
Haptoglobin; Haptoglobin beta chain; Haptoglobin beta polypeptide; Haptoglobin,
alpha polypeptide; HP antibody HP2ALPHA2; HPA1S; HPT_HUMAN; MGC111141; Zonulin.
研究領(lǐng)域；心血管 免疫學
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；Human, (predicted: Mouse, Rat, Dog, Cow, Horse, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；27/43kDa
細胞定位；分泌型蛋白
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human Haptoglobulin beta: 311-406/406
亞 型；IgG
純化方法；affinity purified
by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Haptoglobin (Hp) is a blood plasma protein that
functions to bind free Hemoglobin that has been released from erythrocytes,
thereby inhibiting its oxidative activity. During this process, Haptoglobin
sequesters the iron within Hemoglobin, preventing iron-utilizing bacteria
from benefitting from hemolysis. This function suggests that Haptoglobin
concentrations may increase in response to inflammation. The resulting
Haptoglobin-Hemoglobin complex is then removed by the reticulo-endothelial
system. Due to cleavage of a common precursor protein during protein
synthesis, Haptoglobin consists of two ? and two ∫ chains, connected by disulfide bridges. In human,
Haptoglobin exists in two allelic forms designated Haptoglogin 1 (Hp1) and
Haptoglobin 2 (Hp2), where Hp2 is the result of a partial Hp1 gene
duplication. There are three known phenotypes of human Haptoglobin: Hp1-1,
Hp2-1 and Hp2-2, which may be associated with diabetes and cardiovascular
disease pathology and a susceptibility to Parkinson’s
and Crohn’s disease. Haptoglobin levels are useful in
diagnosing hemolytic anemia, the abnormal breakdown of red blood cells.
Haptoglobin is expressed in mammalian hepatocytes as well as other tissues
such as skin, lung and kidney. As a result of hemolysis, hemoglobin is found to
accumulate in the kidney and is secreted in the urine. Haptoglobin captures,
and combines with free plasma hemoglobin to allow hepatic recycling of heme
iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial;
Antioxidant, has antibacterial activity and plays a role in modulating many
aspects of the acute phase response. Hemoglobin/haptoglobin complexes are
rapidely cleared by the macrophage CD163 scavenger receptor expressed on the
surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin,
plays a role in intestinal permeability, allowing intercellular tight
junction disassembly, and controlling the equilibrium between tolerance and
immunity |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務(wù)。
單項免疫學及檢測服務(wù):
我公司也為客戶提供單項免疫學和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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