簡要描述:鉀/鈉超極化激活環(huán)核苷酸門控通道蛋白2抗體免 疫 原;KLH conjugated synthetic peptide derived from human HCN2: 651-750/889
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鉀/鈉超極化激活環(huán)核苷酸門控通道蛋白2抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
鉀/鈉超極化激活環(huán)核苷酸門控通道蛋白2抗體 | HCN2 | GOY-01K0203 |
商品屬性:
英文名稱: HCN2
中文名:鉀/鈉超極化激活環(huán)核苷酸門控通道蛋白2抗體
別 名;BCNG-2; BCNG2;
HCN 2; Brain cyclic nucleotide gated channel 2; Brain cyclic nucleotide-gated
channel 2; HAC1; Hcn2; HCN2_HUMAN; Potassium/sodium hyperpolarization-activated
cyclic nucleotide-gated channel 2.
研究領(lǐng)域;心血管 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 通道蛋白
抗體來源;Rabbit
克隆類型;Polyclonal
交叉反應(yīng);(predicted:
Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep, )
產(chǎn)品應(yīng)用;WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;97kDa
細(xì)胞定位;細(xì)胞膜
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human HCN2: 651-750/889
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;Preservative:
15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
注意事項(xiàng);This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Hyperpolarization-activated, cyclic
nucleotide-binding channels (HCN) are voltage-gated cation channels that are
activated by direct binding of intracellular cyclic nucleotides. The HCN
family consists of four members (HCN1–4), each with a core transmembrane segment domain and a
carboxy-terminal 120 amino-acid cyclic nucleotide-binding domain motif (1).
HCN channels are expressed in the brain, heart, thalamus and testis (1). The
pacemaker properties of HCN channels contribute to spontaneous rhythmic
activity in the brain and heart (1). The genes encoding human HCN1 and HCN2
map to chromosomes 5 and 19p13.3, respectively (2,3). The genes encoding HCN3
and HCN4 map to chromosomes 1q21.3 and 15q24-q25, respectively (4,5). Hyperpolarization-activated ion channel exhibiting
weak selectivity for potassium over sodium ions. Contributes to the native
pacemaker currents in heart (If) and in neurons (Ih). Produces a large
instantaneous current. Activated by cAMP. Modulated by intracellular chloride
ions and pH; acidic pH shifts the activation to more negative voltages. |
多克隆抗體制備:
我公司合成抗原,保證陽性血清和抗體ELISA效價(jià)達(dá)到1:32000,由蛋白抗原制備的多抗,保證WB檢測(cè)結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行,我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中,與客戶互動(dòng)驗(yàn)證,確保最終制備的抗體ELISA陽性血清檢測(cè)達(dá)到合同要求的同時(shí),也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái),能為客戶提供各種類型的重組抗體表達(dá)服務(wù),包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá),抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù),如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)(如FITC,HRP等的標(biāo)記)、以及ELISA,WB,IHC,DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo),主要用于抗體藥物發(fā)現(xiàn)和開發(fā),是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù),主要面向工業(yè)客戶。
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