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簡要描述：丙肝病毒核心抗原C區(qū)抗體免 疫 原；KLH conjugated synthetic peptide derived from human HCV-Core: 1-50/60
產(chǎn)品型號：GOY-01K0055廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：144產(chǎn)品分類
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丙肝病毒核心抗原C區(qū)抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
丙肝病毒核心抗原C區(qū)抗體 | HCV Core protein | GOY-01K0055 |
商品屬性：
英文名稱: HCV Core protein
中文名:丙肝病毒核心抗原C區(qū)抗體
別 名；Hepatitis C Virus
antigen; Hepatitis C Virus Core 1a; Core protein p19; Hepatitis C Virus Core
Antigen-C; HCVAg; HCV-Core protein;HCV core antigen; HCV core protein;
Hepatitis C Virus core protein; capsid protein; polyprotein precursor; Core
protein p21; Core protein p9.
研究領(lǐng)域；細(xì)胞生物 免疫學(xué) 細(xì)菌及病毒
抗體來源；Rabbit
克隆類型；Polyclonal
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；19/21kDa
細(xì)胞定位；細(xì)胞漿 細(xì)胞膜 分泌型蛋白
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human HCV-Core: 1-50/60
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹:
Core protein packages viral RNA to form a viral
nucleocapsid, and promotes virion budding. Modulates viral translation
initiation by interacting with HCV IRES and 40S ribosomal subunit. Also
regulates many host cellular functions such as signaling pathways and
apoptosis. Prevents the establishment of cellular antiviral state by blocking
the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways
and by inducing human STAT1 degradation. Plays an important role in
virus-mediated cell transformation leading to hepatocellular carcinomas.
Interacts with, and activates STAT3 leading to cellular transformation. May
repress the promoter of p53, and sequester CREB3 and SP110 isoform3/Sp110b in
the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A,
thereby interrupting an important check point of normal cell cycle
regulation. Targets transcription factors involved in the regulation of
inflammatory responses and in the immune response: suppresses NK-kappaB
activation, and activates AP-1. Mediates apoptotic pathways throught
association with TNF-type receptors TNFRSF1A and LTBR, although its effect on
death receptors-induced apoptosis remains controvertial. Enhances TRAIL
mediated apoptosis, suggesting that it might play a role in mediated
apoptosis, suggesting that it might play a role in immune-mediated liver cell
injury. Secreted core protein is able to bind C1QR1 at the T-cell surface,
resulting in down-regulation of T-lymphocytes proliferation. May
transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May
suppress the human FOS and HIV-1 LTR activity. May alter lipid metabolism by
interacting with hepatocellular proteins involved in lipid accumulation and
storage. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進(jìn)行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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