簡要描述：組蛋白去乙?；?+5+9抗體免 疫 原；KLH conjugated synthetic peptide derived from human HDAC4 + 5 + 9: 651-750/1084
產(chǎn)品型號(hào)：GOY-01K0890廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問 量：128產(chǎn)品分類
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組蛋白去乙?；?+5+9抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
組蛋白去乙?；?span lang="EN-US">4+5+9抗體 | HDAC4 + 5 + 9 | GOY-01K0890 |
商品屬性：
英文名稱: HDAC4 + 5 + 9
中文名:組蛋白去乙?；?span lang="EN-US">4+5+9抗體
別 名；AHO3; Antigen
NY-CO-9; BDMR; HA6116; HD4; HD5; HD7; HD7b; HD9; HDAC; HDAC-4; HDACA; HDAC4;
HDAC5; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDACA; HDRP; Histone deacetylase
4; Histone deacetylase 5; Histone deacetylase 7B; Histone deacetylase 9;
Histone deacetylase-related protein; MEF2-interacting transcription repressor
MITR; MITR; NY-CO-9; HDAC4_HUMAN; HDAC5_HUMAN; HDAC9_HUMAN.
研究領(lǐng)域；細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 干細(xì)胞 表觀遺傳學(xué)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；119/122/111kDa
細(xì)胞定位；細(xì)胞核 細(xì)胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human HDAC4 + 5 + 9: 651-750/1084
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
HDAC4 is responsible for the deacetylation of
lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and
H4). Histone deacetylation gives a tag for epigenetic repression and plays an
important role in transcriptional regulation, cell cycle progression and
developmental events. Histone deacetylases act via the formation of large
multiprotein complexes. Involved in muscle maturation via its interaction
with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. HDAC5:
Responsible for the deacetylation of lysine residues on the N-terminal part
of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag
for epigenetic repression and plays an important role in transcriptional
regulation, cell cycle progression and developmental events. Histone
deacetylases act via the formation of large multiprotein complexes. Involved
in muscle maturation by repressing transcription of myocyte enhancer MEF2C.
During muscle differentiation, it shuttles into the cytoplasm, allowing the
expression of myocyte enhancer factors. HDAC9: Responsible for the
deacetylation of lysine residues on the N-terminal part of the core histones
(H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic
repression and plays an important role in transcriptional regulation, cell
cycle progression and developmental events. Represses MEF2-dependent
transcription. Isoform 3 lacks active site residues and therefore is
catalytically inactive. Represses MEF2-dependent transcription by recruiting
HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved
in heart development. Protects neurons from apoptosis, both by inhibiting JUN
phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1
recruitment to JUN promoter. Function: Responsible for the deacetylation of lysine
residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).
Histone deacetylation gi es a tag for epigenetic repression and plays an
important role in transcriptional regulation, cell cycle progression and de
elopmental e ents. Histone deacetylases act ia the formation of large
multiprotein complexes. In ol ed in muscle maturation ia its interaction with
the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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