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簡(jiǎn)要描述：多聚腺苷酸因子Clp1蛋白抗體免 疫 原；KLH conjugated synthetic peptide derived from human HEAB: 1-100/425
產(chǎn)品型號(hào)：GOY-01K4593廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：142產(chǎn)品分類
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多聚腺苷酸因子Clp1蛋白抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
多聚腺苷酸因子Clp1蛋白抗體 | HEAB | GOY-01K4593 |
商品屬性：
英文名稱: HEAB
中文名:多聚腺苷酸因子Clp1蛋白抗體
別 名；ATP/GTP binding protein;
CLP 1; clp1; CLP1 cleavage and polyadenylation factor I subunit homolog; CLP1,
cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae); CLP1,
yeast, homolog of; CLP1_HUMAN; hClp1; Homolog of yeast CFIA subunit Clp1p;
Polynucleotide kinase Clp1; Pre mRNA cleavage complex II protein Clp1; Pre-mRNA
cleavage complex II protein Clp1.
研究領(lǐng)域；細(xì)胞生物 免疫學(xué) 染色質(zhì)和核信號(hào) 表觀遺傳學(xué)
抗體來(lái)源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；48kDa
細(xì)胞定位；細(xì)胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human HEAB: 1-100/425
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
HEAB is a 425 amino acid nuclear protein that
belongs to the Clp1 family. Utilizing magnesium, manganese or nickel as
cofactors, HEAB participates in the phosphorylation of the 5'-hydroxyl groups
of double- and single- stranded RNA and DNA. HEAB is a member of the tRNA
splicing endonuclease complex, in conjunction with TSEN2, TSEN15, TSEN34 and
TSEN54, and is also a member of the pre-mRNA cleavage complex II. The gene
encoding HEAB maps to human chromosome 11q12.1 and mouse chromosome 2 D;
mutations to this gene may lead to a reduced pre-mRNA cleavage activity. HEAB
exists as two isoforms due to alternative splicing events. Polynucleotide kinase that can phosphorylate the
5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA
(ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids.
dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of
a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component.
Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component
of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of
the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a
prerequisite for the subsequent ligation of the two exon halves and the
production of a mature tRNA. Component of the pre-mRNA cleavage complex II
(CF-II), which seems to be required for mRNA 3'-end formation. Also
phosphorylates the 5'-terminus of exogenously introduced short interfering
RNAs (siRNAs), which is a necessary prerequisite for their incorporation into
the RNA-induced silencing complex (RISC). However, endogenous siRNAs and
microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by
DICER1 already contain a 5'-phosphate group, so this protein may be
dispensible for normal RNA-mediated gene silencing. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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