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簡(jiǎn)要描述：腫瘤異常甲基化蛋白2抗體免 疫 原；KLH conjugated synthetic peptide derived from human HIC2 : 501-600/615
產(chǎn)品型號(hào)：GOY-01K2424廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：145產(chǎn)品分類
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腫瘤異常甲基化蛋白2抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
腫瘤異常甲基化蛋白2抗體 | HIC2 | GOY-01K2424 |
商品屬性：
英文名稱: HIC2
中文名:腫瘤異常甲基化蛋白2抗體
別 名；HIC1 related gene
on chromosome 22; HIC2; Hic3; HRG22; Hypermethylated in cancer 2 protein; KIAA1020;
ZBTB30; Zinc finger and BTB domain-containing protein 30; ZNF907; HIC2_HUMAN.
研究領(lǐng)域；染色質(zhì)和核信號(hào) 表觀遺傳學(xué)
抗體來(lái)源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；66kDa
細(xì)胞定位；細(xì)胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human HIC2 : 501-600/615
亞 型；IgG
純化方法；affinity
purified by Protein A
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Zinc-finger proteins contain DNA-binding domains
and have a wide variety of functions, most of which encompass some form of
transcriptional activation or repression. The majority of zinc-finger
proteins contain a Krüppel-type
DNA binding domain and a KRAB domain, which is thought to interact with KAP1,
thereby recruiting histone modifying proteins. HIC-2 (hypermethylated in
cancer 2) possesses zinc finger motifs that are thought to be important for
DNA-binding and also has a BTB/POZ domain at the N-terminus, which is thought
to be important for protein-protein binding, as well as for the binding of
transcription factors. HIC-2 is also known as Hic-3, HIC1-related gene on
chromosome 22 or Zinc finger and BTB domain-containing protein 30, and is a
615 amino acid protein that is expressed as two isoforms produced by
alternative splicing. HIC-2 is highly expressed in cerebellum and is
localized to the nucleus in cells. HIC-2 contains a short amino acid sequence
that is thought to interact with CtBP, a transcriptional repressor. The gene
sequence associated with HIC-2 is thought to be a target for miRNAs
(microRNAs) which are expressed in many cancers, suggesting that HIC-2 could
possess tumor suppressor capabilities. Function: Transcriptional repressor. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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