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簡(jiǎn)要描述：亨廷頓(舞蹈癥)相互作用蛋白1抗體注意事項(xiàng)；This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品型號(hào)：GOY-01K2300廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問 量：164產(chǎn)品分類
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亨廷頓(舞蹈癥)相互作用蛋白1抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
亨廷頓(舞蹈癥)相互作用蛋白1抗體 | HIP1 | GOY-01K2300 |
商品屬性：
英文名稱: HIP1
中文名:亨廷頓(舞蹈癥)相互作用蛋白1抗體
別 名；Huntingtin
Interacting Protein HIP1; HIP I; HIP-1; HIP-I; hip1; HIP1/PDGFRB fusion gene;
HIP1/PDGFRB fusion gene, included; HIP1_HUMAN; HIPI; Huntingtin interacting
protein 1; Huntingtin-interacting protein 1; Huntingtin-interacting protein I;
ILWEQ; KIAA4113; MGC126506; MGC27616; mKIAA4113.
研究領(lǐng)域；細(xì)胞生物 神經(jīng)生物學(xué)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；116kDa
細(xì)胞定位；細(xì)胞核 細(xì)胞漿 細(xì)胞膜
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human HIP1: 401-500/1037
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Huntington disease is associated with the
expansion of a polyglutamine tract, greater than 35 repeats, in the HD gene
product huntingtin. HIP1 (huntingtin-interacting protein 1), a
membrane-associated protein, binds specifically to the N-terminus of human
huntingtin. HIP1 is ubiquitously expressed in different brain regions at low
levels, and exhibits nearly identical subcellular fractionation as
huntingtin. The huntingtin-HIP1 interaction is restricted to the brain and is
inversely correlated to the polyglutamine length in the huntingtin,
suggesting that loss of normal huntingtin-HIP1 interaction may compromise the
membrane-cytoskeletal integrity in the brain. HIP1 contains an endocytic
multidomain protein with a C-terminal Actin-binding domain, a central
coiled-coil forming region and an N-terminal ENTH domain. HIP1 may be
involved in vesicle trafficking; the structural integrity of HIP1 is crucial
for maintenance of normal vesicle size in vivo. HIP12 is a non-proapoptotic
member of the HIP gene family that is expressed in the brain and shares a
similar subcellular distribution pattern with HIP1. However, HIP12 differs
from HIP1 in its pattern of expression at both the mRNA and protein level.
HIP12 does not directly interact with huntingtin but can interact with HIP1. Plays a role in clathrin-mediated endocytosis and
trafficking. Involved in regulating AMPA receptor trafficking in the central
nervous system in an NMDA-dependent manner. Enhances androgen receptor
(AR)-mediated transcription. May act as a proapoptotic protein that induces
cell death by acting through the intrinsic apoptosis pathway. Binds
3-phosphoinositides (via ENTH domain). May act through the ENTH domain to
promote cell survival by stabilizing receptor tyrosine kinases following
ligand-induced endocytosis. May play a functional role in the cell filament
networks. May be required for differentiation, proliferation, and/or survival
of somatic and germline progenitors. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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